ArticleCurrent biology : CB2017
Ionotropic Receptors Mediate Drosophila Oviposition Preference through Sour Gustatory Receptor Neurons.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Contrasting Oviposition Preference Despite Limited Chemosensory Receptor Gene Differentiation in Two Cryptic Anopheles Species.Molecular ecology · 2026Article
- Humidity as a potential zeitgeber for circadian entrainment of insect systems.Npj biological timing and sleep · 2026Article
- Space-Dependent Oviposition Preference in Drosophila.Neuroscience bulletin · 2026Article
- Gustatory sensing by ovipositor drives maternal avoidance of hesperidin to benefit the offspring in a major agricultural fly pest.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Modulation of attractive salt taste iniScience · 2026Article
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- Transposable elements contribute to the evolution of host shift-related genes in cactophilicGenome research · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Behavioral divergence between a generalist and a specialist mosquito despite minimal differentiation across chemosensory receptor gene families.bioRxiv : the preprint server for biology · 2025Article
- An Orco dependent pathway suppresses egg-laying attraction to ripe fruit volatile compounds in Drosophila melanogaster but not in D. suzukii.BMC ecology and evolution · 2025Article
- Stress-induced preference for antioxidants byProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome-Wide Identification and Evolutionary Analysis ofAnimals : an open access journal from MDPI · 2025Article
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- The conserved IR75 subfamily mediates carboxylic acid detection in insects of public health and agricultural importance.Journal of insect science (Online) · 2025Review
- Cross-modal sensory compensation increases mosquito attraction to humans.Science advances · 2025Article
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- Molecular and cellular basis of sodium sensing iniScience · 2024Article
- The egg-counter: a novel microfluidic platform for characterization ofLab on a chip · 2024Article
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- An advanced metabolomic approach on grape skins untangles cultivar preferences byFrontiers in plant science · 2024Article
6 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Carboxylic acids are present in many foods, being especially abundant in fruits. Yet, relatively little is known about how acids are detected by gustatory systems and whether they have a potential role in nutrition or provide other health benefits. Here we identify sour gustatory receptor neurons (GRNs) in tarsal taste sensilla of Drosophila melanogaster. We find that most tarsal sensilla harbor a sour GRN that is specifically activated by carboxylic and mineral acids but does not respond to sweet- and bitter-tasting chemicals or salt. One pair of taste sensilla features two GRNs that respond only to a subset of carboxylic acids and high concentrations of salt. All sour GRNs prominently express two Ionotropic Receptor (IR) genes, IR76b and IR25a, and we show that both these genes are necessary for the detection of acids. Furthermore, we establish that IR25a and IR76b are essential in sour GRNs of females for oviposition preference on acid-containing food. Our investigations reveal that acids activate a unique set of taste cells largely dedicated to sour taste, and they indicate that both pH/proton concentration and the structure of carboxylic acids contribute to sour GRN activation. Together, our studies provide new insights into the cellular and molecular basis of sour taste.
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