Evidence map›Paper›PMID 28889481›Full record

ReviewCancer science2018

Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T-cell lymphoma.

Kota Fukumoto, Tran B Nguyen, Shigeru Chiba, Mamiko Sakata-Yanagimoto

Open access · goldAbstract readReview
In one paragraph

Review in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. [Analysis of clinicopathological and molecular abnormalities of angioimmunoblastic T-cell lymphoma].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023
    Article
  7. TheCancers · 2023
    Article
  8. DNMT3AOncogene · 2023
    Article
  9. Article
  10. Metabolic determinants of tumour initiation.Nature reviews. Endocrinology · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. How I Diagnose Angioimmunoblastic T-Cell Lymphoma.American journal of clinical pathology · 2021
    Review
  18. Article
  19. Review
  20. Update on recurrent mutations in angioimmunoblastic T-cell lymphoma.International journal of clinical and experimental pathology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kota FukumotoDepartment of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.ORCID http://orcid.org/0000-0002-2729-5780
Tran B NguyenDepartment of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.
Shigeru ChibaDepartment of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.
Mamiko Sakata-YanagimotoDepartment of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.
University of Tsukuba Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is an age-related malignant lymphoma, characterized by immune system-dysregulated symptoms. Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha (DNMT3A) and isocitrate dehydrogenase 2, mitochondrial (IDH2), as well as those related to the T-cell receptor signaling pathway in AITL. In this review, we focus on how this genetic information has changed the understanding of the developmental process of AITL and will in future lead to individualized therapies for AITL patients.

Indexed as

Gene Regulatory NetworksMutationDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AEpigenesis, GeneticGenetic Predisposition to DiseaseHumansImmunoblastic LymphadenopathyIsocitrate DehydrogenaseLymphoma, T-CellProto-Oncogene ProteinsReceptors, Antigen, T-CellrhoA GTP-Binding ProteinSignal TransductionDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanIDH2 protein, humanIsocitrate DehydrogenaseProto-Oncogene ProteinsReceptors, Antigen, T-CellrhoA GTP-Binding ProteinRHOA protein, humanTET2 protein, humanangioimmunoblastic T-cell lymphomaepigenetic regulatormultistep and multilineage tumorigenesisras homology family member AT-cell receptor-signaling

Identifiers

PMID28889481
PMCPMC5834775
OpenAlexW2752283479

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.