Evidence map›Paper›PMID 28889355›Full record

ArticleInflammopharmacology2018

Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to cannabinoid receptors activation in mice.

C C Veloso, R C M Ferreira, V G Rodrigues, L P Duarte, A Klein, I D Duarte, T R L Romero, A C Perez

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Targeting L-arginine/NO/cGMP/KFrontiers in pharmacology · 2025
    Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

C C VelosoFaculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas (UFAM), Av. General Rodrigo Octávio Jordão Ramos, 3000, Coroado I, Manaus, AM, 69.077-000, Brazil. clariceveloso@ufam.edu.br.
R C M FerreiraDepartment of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
V G RodriguesDepartment of Chemistry, Institute of Exact Sciences, UFMG, Belo Horizonte, MG, Brazil.
L P DuarteDepartment of Chemistry, Institute of Exact Sciences, UFMG, Belo Horizonte, MG, Brazil.
A KleinDepartment of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
I D DuarteDepartment of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
T R L RomeroDepartment of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
A C PerezDepartment of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade Federal do Amazonas · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-Brazil) and Conselho Nacional de Pesquisa (CNPq-Brazil) 3536130
6 · The paper itself

Abstract

Several works have shown that triterpenes induce peripheral antinociception by activation of cannabinoid receptors and endocannabinoids; besides, several research groups have reported activation of cannabinoid receptors in peripheral antinociception. The aim of this study was to assess the involvement of the cannabinoid system in the antinociceptive effect induced by tingenone against hyperalgesia evoked by prostaglandin E

Indexed as

AmidohydrolasesAnalgesicsAnimalsArachidonic AcidsBenzodioxolesCannabinoid Receptor AgonistsCannabinoidsEndocannabinoidsFatty Acid Amide HydrolasesHyperalgesiaIndolesMaleMiceMonoacylglycerol LipasesPentacyclic TriterpenesPiperidinesAM 251AmidohydrolasesAnalgesicsanandamideArachidonic AcidsBenzodioxolesCannabinoid Receptor AgonistsCannabinoidsEndocannabinoidsFatty Acid Amide HydrolasesIndolesiodopravadolineJZL 184Monoacylglycerol LipasesN-(2-methyl-3-hydroxyphenyl)-5,8,11,14-eicosatetraenamidePentacyclic TriterpenesPiperidinesPolyunsaturated AlkamidesPyrazolesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2tingenoneTriterpenesCannabinoid receptorsPentacyclic triterpenePeripheral antinociceptionTingenone

Identifiers

PMID28889355
OpenAlexW2756243738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.