ArticleIrish journal of medical science2018
Gene expression and levels of IL-6 and TNFα in PBMCs correlate with severity and functional class in patients with chronic heart failure.
Article in Irish journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Simvastatin Combined with Resistance Training Improves Outcomes in Patients with Chronic Heart Failure by Modulating Mitochondrial Membrane Potential and the Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathways.Cardiovascular therapeutics · 2022Trial
- Childhood adversity and increased cytokine release from peripheral mononuclear cells of CHD patients - a pilot study.BMC cardiovascular disorders · 2026Article
- Investigation of adherence to DASH diet components and reduction of heart failure risk in adults: A case-control study.ARYA atherosclerosis · 2024Article
- The function of miRNAs in the immune system's inflammatory reaction to heart failure.Frontiers in cardiovascular medicine · 2024Review
- Inflammation in acute heart failure.Frontiers in cardiovascular medicine · 2023Review
- Plasma-derived exosomes implement miR-126-associated regulation of cytokines secretion in PBMCs of CHF patients in vitro.Acta bio-medica : Atenei Parmensis · 2022Article
- Psychosomatic syndromes are associated with IL-6 pro-inflammatory cytokine in heart failure patients.PloS one · 2022Article
- The Role of Interleukin-6 Family Members in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2022Review
- Inflammation-Related Biomarkers Are Associated with Heart Failure Severity and Poor Clinical Outcomes in Patients with Non-Ischemic Dilated Cardiomyopathy.Life (Basel, Switzerland) · 2021Article
- Coronavirus Disease-2019 (COVID-19) and Cardiovascular Complications.Journal of cardiothoracic and vascular anesthesia · 2021Review
- Role of some serum biomarkers in the early detection of diabetic cardiomyopathy.Future science OA · 2021Article
- Unlocking the Value of White Blood Cells for Heart Failure Diagnosis.Journal of cardiovascular translational research · 2021Review
- Myocardial ischemia-reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury.Journal of extracellular vesicles · 2021Article
- CMV Infection Is Directly Related to the Inflammatory Status in Chronic Heart Failure Patients.Frontiers in immunology · 2021Article
- Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene.Oxidative medicine and cellular longevity · 2021Article
- Early Changes in Circulating Interleukins and Residual Inflammatory Risk After Acute Myocardial Infarction.Arquivos brasileiros de cardiologia · 2020Article
- Epigallocatechin-3-gallate ameliorates LPS-induced inflammation by inhibiting the phosphorylation of Akt and ERK signaling molecules in rat H9c2 cells.Experimental and therapeutic medicine · 2020Article
- Effect of syringic acid and syringaldehyde on oxidative stress and inflammatory status in peripheral blood mononuclear cells from patients of myocardial infarction.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Role of cytokines and inflammation in heart function during health and disease.Heart failure reviews · 2018Review
- Association of levels of interleukin 17 and T-helper 17 count with symptom severity and etiology of chronic heart failure: a case-control study.Croatian medical journal · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence shows that proinflammatory cytokines are important determinants of assessment of severity and prognosis of chronic heart failure (CHF).
aimsWe investigated whether peripheral expression of the proinflammmatory factors, TNF-α and IL-6 can predict variable of clinical assessment of patients with CHF.
methodsIn this report, we used real-time PCR assay to compare relative gene expression of TNFα and IL-6 in PBMC from CHF patients with various heart diseases (n = 42, EF < 45%, NYHA I to IV) and matched healthy control subjects (n = 42).We also determined the TNFα and IL-6 concentrations of cell culture supernatant of PBMCs with ELISA.
resultsThere was a significant negative correlation between gene expression of TNFα and LVEF(r = 0.4, p < 0.05). Patients with CHF had increased gene expression of TNFα and IL-6 in PBMCs (p < 0.05). They also had elevated the supernatant levels of these cytokines in cultured PBMCs (p < 0.001). Levels of TNFα and IL-6 were increased in ischemic heart disease compared to non-ischemic heart disease. There was a positive correlation between TNFα and IL-6 levels in CHF patients and severity of CHF in patients. Levels of these cytokines were higher in patients with NYHA III-IV than in NYHA I-II and normal subjects.
conclusionsResults of this study indicate that peripheral expression of proinflammatory cytokines, TNF-α and IL-6, is important indicators of severity and prognosis in patients with chronic heart disease.
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