ArticleNeuroradiology2017
Motor-related brain abnormalities in HIV-infected patients: a multimodal MRI study.
Article in Neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Different roles of frontal versus striatal atrophy in HIV-associated neurocognitive disorders.Human brain mapping · 2019Pooled it
- Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Characteristics of cortical thickness in treated HIV-infected individuals with and without cognitive impairment.European journal of medical research · 2025Article
- Altered angular gyrus activation during the digit symbol substitution test in people living with HIV: beyond information processing speed deficits.Scientific reports · 2025Article
- Alterations in local activity and whole-brain functional connectivity in human immunodeficiency virus-associated neurocognitive disorders: a resting-state functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2025Article
- Human immunodeficiency virus accelerates brain aging and disrupts the trajectory of glymphatic clearance in aging brain.Frontiers in psychiatry · 2025Article
- Divergent structural and functional brain alterations in HIV-infected patients: a multimodal meta-analysis.Frontiers in neurology · 2025Review
- Leveraging Brain Modularity Prior for Interpretable Representation Learning of fMRI.IEEE transactions on bio-medical engineering · 2024Article
- Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder.Neurobiology of disease · 2023Article
- Mitochondrial redox environments predict sensorimotor brain-behavior dynamics in adults with HIV.Brain, behavior, and immunity · 2023Article
- Article
- Neurological soft signs and brain morphology in people living with HIV.Journal of neurovirology · 2022Article
- Morphological Changes of Frontal Areas in Male Individuals With HIV: A Deformation-Based Morphometry Analysis.Frontiers in neurology · 2022Article
- HIV infection is linked with reduced error-related default mode network suppression and poorer medication management abilities.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Longitudinal trajectories of brain volume in combined antiretroviral therapy treated and untreated simian immunodeficiency virus-infected rhesus macaques.AIDS (London, England) · 2021Article
- Human immunodeficiency virus-related decreases in corpus callosal integrity and corresponding increases in functional connectivity.Human brain mapping · 2021Article
- Characteristics of Motor Dysfunction in Longstanding Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Effects of HIV infection, antiretroviral therapy, and immune status on the speed of information processing and complex motor functions in adult Cameroonians.Scientific reports · 2020Article
- Atypical Resting-State Functional Connectivity Dynamics Correlate With Early Cognitive Dysfunction in HIV Infection.Frontiers in neurology · 2020Article
- Heterogeneity in neurocognitive change trajectories among people with HIV starting antiretroviral therapy in Rakai, Uganda.Journal of neurovirology · 2019Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt is generally believed that HIV infection could cause HIV-associated neurocognitive disorders (HAND) across a broad range of functional domains. Some of the most common findings are deficits in motor control. However, to date no neuroimaging studies have evaluated basic motor control in HIV-infected patients using a multimodal approach.
methodsIn this study, we utilized high-resolution structural imaging and task-state functional magnetic resonance imaging (fMRI) to assess brain structure and motor function in a homogeneous cohort of HIV-infected patients.
resultsWe found that HIV-infected patients had significantly reduced gray matter (GM) volume in cortical regions, which are involved in motor control, including the bilateral posterior insula cortex, premotor cortex, and supramarginal gyrus. Increased activation in bilateral posterior insula cortices was also demonstrated by patients during hand movement tasks compared with healthy controls. More importantly, the reduced GM in bilateral posterior insula cortices was spatially coincident with abnormal brain activation in HIV-infected patients. In addition, the results of partial correlation analysis indicated that GM reduction in bilateral posterior insula cortices and premotor cortices was significantly correlated with immune system deterioration.
conclusionThis study is the first to demonstrate spatially coincident GM reduction and abnormal activation during motor performance in HIV-infected patients. Although it remains unknown whether the brain deficits can be recovered, our findings may yield new insights into neurologic injury underlying motor dysfunction in HAND.
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