ArticleDiabetologia2017
The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study.
Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 6 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Impact of Glucagon-like Peptide-1 Receptor Agonists on Mental Illness: Evidence from a Mendelian Randomization Study.International journal of molecular sciences · 2025Pooled it
- The prevalence of dyslipidemia and its correlation with anti-retroviral therapy among people living with HIV in China: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies.Journal of the American Heart Association · 2023Pooled it
- SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study.Diabetes care · 2022Pooled it
- Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases.Frontiers in cellular and infection microbiology · 2022Pooled it
- Assessing the causal impact of leisure-time physical activity and screen time on lifespan: a Mendelian randomization study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Metabolic mediators linking type 1 diabetes mellitus to osteoporosis.Archives of medical science : AMS · 2026Article
- Non-HDL-to-HDL cholesterol ratio predicts incident T2DM and CHD in non-alcoholic fatty liver disease: evidence from a large clinical cohort and NHANES.Frontiers in nutrition · 2026Article
- The impact of immune cells on the risk of breast cancer: a Mendelian randomization study.Discover oncology · 2025Article
- Genetic Evidence Linking Lipoprotein(a) to Cardiovascular Disease and the Potential Role of Aspirin: A Mendelian Randomization Study.Reviews in cardiovascular medicine · 2025Article
- A one-shot, lossless algorithm for cross-cohort learning in mixed-outcomes analysis.Patterns (New York, N.Y.) · 2025Article
- MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality.Nature communications · 2025Article
- Evaluating the impact of metabolic indicators and scores on cardiovascular events using machine learning.Diabetology & metabolic syndrome · 2025Article
- Investigating whether smoking and alcohol behaviours influence risk of type 2 diabetes using a Mendelian randomisation study.Scientific reports · 2025Article
- The role of circulating polyunsaturated fatty acids in mediating the effect of BMI on leukocyte telomere length: analysis using Mendelian randomization.Nutrition & metabolism · 2024Article
- Socioeconomic traits and the risk of Barrett's esophagus and gastroesophageal reflux disease: A Mendelian randomization study.World journal of gastrointestinal oncology · 2024Article
- Coffee intake reduced gout risk by decreasing urate and urea while increasing SHBG levels in plasma: a mediation Mendelian randomization study.Clinical rheumatology · 2024Article
- The impact of reproductive factors on the metabolic profile of females from menarche to menopause.Nature communications · 2024Article
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
aims/hypothesisThe extent to which effects of BMI on CHD are mediated by glycaemic and lipid risk factors is unclear. In this study we examined the effects of these traits using genetic evidence.
methodsWe used two-sample Mendelian randomisation to determine: (1) the causal effect of BMI on CHD (60,801 case vs 123,504 control participants), type 2 diabetes (34,840 case vs 114,981 control participants), fasting glucose (n = 46,186), insulin (n = 38,238), HbA
resultsOne SD higher BMI (~ 4.5 kg/m CONCLUSIONS/
interpretationIncreased triacylglycerol levels and poor glycaemic control appear to mediate much of the effect of BMI on CHD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.