Evidence map›Paper›PMID 28888963›Full record

ArticleNeurochemistry international2018

Sex differences in the mitochondrial bioenergetics of astrocytes but not microglia at a physiologically relevant brain oxygen tension.

Sausan M Jaber, Evan A Bordt, Niraj M Bhatt, Daniel M Lewis, Sharon Gerecht, Gary Fiskum, Brian M Polster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemistry international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. HAPI Cells are SIM-A9-related Mouse Microglial Cells Useful forbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Sex differences in cancer mechanisms.Biology of sex differences · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sausan M JaberDepartment of Anesthesiology, and the Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, 685 W. Baltimore ST., MSTF 5-34, Baltimore, MD, 21201, USA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 685 W. Baltimore ST., MSTF 5-34, Baltimore, MD, 21201, USA.
Evan A BordtDepartment of Anesthesiology, and the Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, 685 W. Baltimore ST., MSTF 5-34, Baltimore, MD, 21201, USA.
Niraj M BhattDepartment of Anesthesiology, and the Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, 685 W. Baltimore ST., MSTF 5-34, Baltimore, MD, 21201, USA.
Daniel M LewisDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, 3400 North Charles Street, Shaffer Hall 200C, Baltimore, MD 21218, USA.
Sharon GerechtDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, 3400 North Charles Street, Shaffer Hall 200C, Baltimore, MD 21218, USA; Department of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, Shaffer Hall 200C, Baltimore, MD 21218, USA.
Gary FiskumDepartment of Anesthesiology, and the Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, 685 W. Baltimore ST., MSTF 5-34, Baltimore, MD, 21201, USA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 685 W. Baltimore ST., MSTF 5-34, Baltimore, MD, 21201, USA.
Brian M PolsterDepartment of Anesthesiology, and the Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, 685 W. Baltimore ST., MSTF 5-34, Baltimore, MD, 21201, USA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 685 W. Baltimore ST., MSTF 5-34, Baltimore, MD, 21201, USA. Electronic address: bpolster@som.umaryland.edu.

Funding

EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
SPECTRIN-DEPENDENT MEMBRANE DOMAINS IN THE DEVELOPING CNSP01HD016596 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI MCKENNA, MARY C · 1985 to 2013
$12.8M
T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5M
Optimal Oxygenation and Gene Expression During Critical Care after Cardiac ArrestR01NS091099 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI FISKUM, GARY M, ROSENTHAL, ROBERT EDWARD · 2015 to 2019
$2.2M
Novel Mechanisms of Microglial Neurotoxicity at Physiological OxygenR01NS085165 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI POLSTER, BRIAN M · 2013 to 2017
$1.7M
T-32 NIH Postdoctoral Training Program in Nanotechnology for Cancer Medicine NTCMT32CA130840 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2008 to 2012
$1.2M
Mitochondrial Structural and Functional Remodeling in Microglial ActivationR21NS096538 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI POLSTER, BRIAN M · 2016 to 2017
$424k
NCI NIH HHS T32 CA130840NCI NIH HHS T32 CA153952NICHD NIH HHS P01 HD016596NIGMS NIH HHS R25 GM055036NINDS NIH HHS R01 NS085165NINDS NIH HHS R01 NS091099NINDS NIH HHS R21 NS096538
6 · The paper itself

Abstract

Biological sex is thought to influence mitochondrial bioenergetic function. Previous respiration measurements examining brain mitochondrial sex differences were made at atmospheric oxygen using isolated brain mitochondria. Oxygen is 160 mm Hg (21%) in the atmosphere, while the oxygen tension in the brain generally ranges from ∼5 to 45 mm Hg (∼1-6% O

Indexed as

Sex CharacteristicsAnimalsAnimals, NewbornAstrocytesBrainCells, CulturedEnergy MetabolismFemaleMaleMicrogliaMitochondriaOxygen ConsumptionRatsRats, Sprague-DawleyCytokineGenderHyperoxiaHypoxiaLipopolysaccharideRespiration

Identifiers

PMID28888963
PMCPMC5839942

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.