Evidence map›Paper›PMID 28888943›Full record

ArticleNeuropharmacology2018

Melanin concentrating hormone modulates oxytocin-mediated marble burying.

Nayna M Sanathara, Celia Garau, Amal Alachkar, Lien Wang, Zhiwei Wang, Katsuhiko Nishimori, Xiangmin Xu, Olivier Civelli

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

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  11. Neural Contributions of the Hypothalamus to Parental Behaviour.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Nayna M SanatharaDepartment of Pharmacology, University of California, Irvine, CA, 92697, USA.
Celia GarauDepartment of Pharmaceutical Sciences, University of California, Irvine, CA, 92697, USA.
Amal AlachkarDepartment of Pharmacology, University of California, Irvine, CA, 92697, USA.
Lien WangDepartment of Pharmacology, University of California, Irvine, CA, 92697, USA.
Zhiwei WangDepartment of Pharmacology, University of California, Irvine, CA, 92697, USA.
Katsuhiko NishimoriDepartment of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai, Miyagi, 981-8555, Japan.
Xiangmin XuDepartment of Anatomy and Neurobiology, University of California, Irvine, CA, 92697, USA.
Olivier CivelliDepartment of Pharmacology, University of California, Irvine, CA, 92697, USA; Department of Pharmaceutical Sciences, University of California, Irvine, CA, 92697, USA; Department of Developmental and Cell Biology, University of California, Irvine, CA, 92697, USA. Electronic address: ocivelli@uci.edu.
University of California, Irvine · USTohoku University · JP

Funding

Inhibitory neuron circuit organization and function in prefrontal cortex.R01MH105427 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLSHANI, PEYMAN, XU, XIANGMIN · 2015 to 2019
$2.3M
Neural circuit organization and function of the bed nucleus of the stria terminalisR01MH113026 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2017 to 2021
$2.2M
Hippocampal inhibitory neuronal circuit organizationR01NS078434 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2012 to 2016
$1.6M
A novel neuropeptide system involved in drug abuseR01DA024746 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CIVELLI, OLIVIER · 2010 to 2013
$1.5M
NIDA NIH HHS R01 DA024746NIMH NIH HHS R01 MH105427NIMH NIH HHS R01 MH113026NINDS NIH HHS R01 NS078434
6 · The paper itself

Abstract

Repetitive and perseverative behaviors are common features of a number of neuropsychiatric diseases such as Angelman's syndrome, Tourette's syndrome, obsessive-compulsive disorder, and autism spectrum disorders. The oxytocin system has been linked to the regulation of repetitive behavior in both animal models and humans, but many of its downstream targets have still to be found. We report that the melanin-concentrating hormone (MCH) system is a target of the oxytocin system in regulating one repetitive behavior, marble burying. First we report that nearly 60% of MCH neurons express oxytocin receptors, and demonstrate using rabies mediated tract tracing that MCH neurons receive direct presynaptic input from oxytocin neurons. Then we show that MCH receptor knockout (MCHR1KO) mice and MCH ablated animals display increased marble burying response while central MCH infusion decreases it. Finally, we demonstrate the downstream role of the MCH system on oxytocin mediated marble burying by showing that central infusions of MCH and oxytocin alone or together reduce it while antagonizing the MCH system blocks oxytocin-mediated reduction of this behavior. Our findings reveal a novel role for the MCH system as a mediator of the role of oxytocin in regulating marble-burying behavior in mice.

Indexed as

Adaptation, OcularAnalysis of VarianceAnimalsDiphtheria ToxinExploratory BehaviorGlycoproteinsGreen Fluorescent ProteinsGroomingHypothalamic HormonesLuminescent ProteinsMaleMaze LearningMelaninsMiceMice, Inbred C57BLMice, Transgenic6-(4-chlorophenyl)-3-(3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl)-3H-thieno(3,2-d)pyrimidin-4-oneDiphtheria ToxinGlycoproteinsGreen Fluorescent ProteinsHypothalamic HormonesLuminescent ProteinsMchr1 protein, mousemelanin-concentrating hormoneMelaninsOXTR protein, mouseOxytocinPituitary HormonesPyrimidinonesReceptors, OxytocinReceptors, SomatostatinRed Fluorescent ProteinThiophenesMCHR1Orbitofrontal cortexPerseverative behaviorRabies circuit mapping

Identifiers

PMID28888943
PMCPMC5830107
OpenAlexW2751988976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.