Evidence map›Paper›PMID 28888927›Full record

Trial reportThe lancet. Psychiatry2017

The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis.

Daniel Freeman, Bryony Sheaves, Guy M Goodwin, Ly-Mee Yu, Alecia Nickless, Paul J Harrison, Richard Emsley, Annemarie I Luik, Russell G Foster, Vanashree Wadekar and 32 more

Registry-linked trialOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The lancet. Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05568381 (Sleep Disturbance in MCI), which is not on this map. Cited by 305 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
305citing papers in PubMed, 18 pooled it
48.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05568381 nacompletednot on this mapstarted 2023, after this paper: background citation

Sleep Disturbance in MCI: A Pilot Study of a Cognitive Behavioural Therapy Digital Intervention (SUCCEED)

TypeinterventionalSponsorUniversity of SydneyRan2023 to 2023Enrolled40ConditionsCognitive Dysfunction, Insomnia, Mild Cognitive Impairment, Cognitive DisorderArmsdigital CBT-I, Online Sleep Health Education package
3 · Its place in the literature

Who cites it

305 citing papers in PubMed, 18 syntheses or guidelines pooled it, 654 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. A Systematic Review of the Reporting Quality of Observational Studies That Use Mediation Analyses.Prevention science : the official journal of the Society for Prevention Research · 2022
    Pooled it
  17. Pooled it
  18. Pooled it
  19. Trial
  20. Trial

245 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 1 country.

Daniel FreemanDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK; Oxford Health National Health Service (NHS) Foundation Trust, Oxford, UK. Electronic address: daniel.freeman@psych.ox.ac.uk.
Bryony SheavesDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK; Oxford Health National Health Service (NHS) Foundation Trust, Oxford, UK.
Guy M GoodwinDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK; Oxford Health National Health Service (NHS) Foundation Trust, Oxford, UK.
Ly-Mee YuNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Alecia NicklessNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Paul J HarrisonDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK; Oxford Health National Health Service (NHS) Foundation Trust, Oxford, UK.
Richard EmsleyCentre for Biostatistics, Institute of Population Health, Manchester University, Manchester Academic Health Centre, Manchester, UK.
Annemarie I LuikSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Sir William Dunn School of Pathology, Oxford, UK; Big Health Ltd, London, UK.
Russell G FosterSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Sir William Dunn School of Pathology, Oxford, UK.
Vanashree WadekarDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Christopher HindsDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Andrew GumleyInstitute of Health and Wellbeing, University of Glasgow, Gartnavel Royal Hospital, Glasgow, UK.
Ray JonesSchool of Nursing and Midwifery, Faculty of Health and Human Sciences, Plymouth University, Plymouth, UK.
Stafford LightmanHenry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK.
Steve JonesSpectrum Centre for Mental Health Research, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
Richard BentallClinical Psychology Unit, Department of Psychology, University of Sheffield, Sheffield, UK.
Peter KindermanPsychological Sciences, Institute of Psychology Health and Society, University of Liverpool, Liverpool, UK.
Georgina RowseClinical Psychology Unit, Department of Psychology, University of Sheffield, Sheffield, UK.
Traolach BrughaDepartment of Health Sciences, College of Medicine, Biological Sciences and Psychology, Centre for Medicine, University of Leicester, Leicester, UK.
Mark BlagroveDepartment of Psychology, University of Swansea, Swansea, UK.
Alice M GregoryDepartment of Psychology, Goldsmiths, University of London, London, UK.
Leanne FlemingDepartment of Psychology, University of Strathclyde, Glasgow, UK.
Elaine WalkletDepartment of Psychology, Institute of Health and Society, University of Worcester, Worcester, UK.
Cris GlazebrookDivision of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, UK; National Institute for Healthcare Research MindTech Healthcare Technology Co-operative, Institute of Mental Health, University of Nottingham, Nottingham, UK.
E Bethan DaviesNational Institute for Healthcare Research MindTech Healthcare Technology Co-operative, Institute of Mental Health, University of Nottingham, Nottingham, UK.
Chris HollisDivision of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, UK; National Institute for Healthcare Research MindTech Healthcare Technology Co-operative, Institute of Mental Health, University of Nottingham, Nottingham, UK.
Gillian HaddockDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, Manchester, UK.
Bev JohnSchool of Psychology and Therapeutic Studies, University of South Wales, Treforest, UK.
Mark CoulsonDepartment of Psychology, School of Science and Technology, University of Middlesex, London, UK.
David FowlerDepartment of Psychology, University of Sussex, Brighton, UK; Sussex Partnership NHS Foundation Trust, Worthing, UK.
Katherine PughSussex Partnership NHS Foundation Trust, Worthing, UK.
John CapeDepartment of Clinical, Educational and Health Psychology, University College London, London, UK.
Peter MoseleySchool of Psychology, University of Central Lancashire, Preston, UK.
Gary BrownPsychology Department, Royal Holloway, Egham, UK.
Claire HughesUniversity of Cambridge Centre for Family Research, Cambridge, UK.
Marc ObonsawinSchool of Psychological Sciences and Health, University of Strathclyde, Glasgow UK.
Sian CokerDepartment of Clinical Psychology, Norwich Medical School, University of East Anglia, Norwich, UK.
Edward WatkinsSMART Lab, College of Life and Environmental Sciences, Sir Henry Wellcome Building for Mood Disorders Research, University of Exeter, Exeter, UK.
Matthias SchwannauerSchool of Health in Social Sciences, University of Edinburgh, Medical School, Edinburgh, UK.
Kenneth MacMahonSchool of Health in Social Sciences, University of Edinburgh, Medical School, Edinburgh, UK.
A Niroshan SiriwardenaCommunity and Health Research Unit, University of Lincoln, Lincoln, UK.
Colin A EspieSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Sir William Dunn School of Pathology, Oxford, UK; Big Health Ltd, London, UK.
University of Oxford · GBNational Health Service · GBNIHR MindTech MedTech Co-operative · GBManchester Academic Health Science Centre · GBSussex Partnership NHS Foundation Trust · GBUniversity of Edinburgh · GBUniversity of Sheffield · GBUniversity of Strathclyde · GBCentre for Mental Health · GBGartnavel General Hospital · GBGoldsmiths University of London · GBMiddlesex University · GBRoyal Holloway University of London · GBSwansea University · GBUniversity College London · GBUniversity of Bristol · GBUniversity of Cambridge · GBUniversity of Central Lancashire · GBUniversity of East Anglia · GBUniversity of Exeter · GB

Funding

Department of Health RP-2014-05-003Wellcome TrustWellcome Trust 098461/Z/12/Z
6 · The paper itself

Abstract

backgroundSleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduction in paranoia and hallucinations.

methodsWe did this single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with insomnia were randomly assigned (1:1) with simple randomisation to receive digital cognitive behavioural therapy (CBT) for insomnia or usual care, and the research team were masked to the treatment. Online assessments took place at weeks 0, 3, 10 (end of therapy), and 22. The primary outcome measures were for insomnia, paranoia, and hallucinatory experiences. We did intention-to-treat analyses. The trial is registered with the ISRCTN registry, number ISRCTN61272251.

findingsBetween March 5, 2015, and Feb 17, 2016, we randomly assigned 3755 participants to receive digital CBT for insomnia (n=1891) or usual practice (n=1864). Compared with usual practice, the sleep intervention at 10 weeks reduced insomnia (adjusted difference 4·78, 95% CI 4·29 to 5·26, Cohen's d=1·11; p<0·0001), paranoia (-2·22, -2·98 to -1·45, Cohen's d=0·19; p<0·0001), and hallucinations (-1·58, -1·98 to -1·18, Cohen's d=0·24; p<0·0001). Insomnia was a mediator of change in paranoia and hallucinations. No adverse events were reported.

interpretationTo our knowledge, this is the largest randomised controlled trial of a psychological intervention for a mental health problem. It provides strong evidence that insomnia is a causal factor in the occurrence of psychotic experiences and other mental health problems. Whether the results generalise beyond a student population requires testing. The treatment of disrupted sleep might require a higher priority in mental health provision.

fundingWellcome Trust.

Indexed as

AdolescentAdultCognitive Behavioral TherapyFemaleHallucinationsHumansMaleMental HealthParanoid DisordersSleepSleep Initiation and Maintenance DisordersStudentsTreatment OutcomeUnited KingdomYoung Adult

Identifiers

PMID28888927
PMCPMC5614772
OpenAlexW2753665614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.