ReviewAmerican journal of obstetrics and gynecology2018
Nonsteroidal antiinflammatory drug resistance in dysmenorrhea: epidemiology, causes, and treatment.
Review in American journal of obstetrics and gynecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03697720 (Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain), which is not on this map. Cited by 108 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain
Who cites it
108 citing papers in PubMed, 8 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Pharmacological insights intoFrontiers in pharmacology · 2025Pooled it
- Social Determinants of Health and Dysmenorrhea: A Systematic Review.The journal of pain · 2024Pooled it
- Transcutaneous electrical nerve stimulation (TENS) for pain control in women with primary dysmenorrhoea.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness and safety of Chinese herbal footbaths as an adjuvant therapy for dysmenorrhea: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Efficacy and Safety of Acupuncture and or Moxibustion for Managing Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.Clinical nursing research · 2022Pooled it
- Efficacy of herbal medicine (cinnamon/fennel/ginger) for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials.The Journal of international medical research · 2020Pooled it
- Efficacy of phloroglucinol for the treatment of pain of gynaecologic or obstetrical origin: a systematic review of literature of randomised controlled trials.European journal of clinical pharmacology · 2020Pooled it
- Seeking the root causes of menstrual pain: A systematic review of biomarkers in menstrual effluent.Molecular painPooled it
- Benefits of fresh strawberries consumption from Huelva in primary dysmenorrhea: a randomized controlled pilot trial.Frontiers in nutrition · 2026Trial
- Impact of Adlay-Based Formula on Pain and Discomfort in Women with Dysmenorrhea: A Randomized Controlled Trial.Nutrients · 2024Trial
- Efficacy and Safety of Sanjie Analgesic Capsule in Patients with Endometriosis-Associated Pain: A Multicenter, 3:1 Randomized, Double-Blind, Placebo-Controlled Trial.Chinese journal of integrative medicine · 2024Trial
- Clinical observation on 90 cases of primary dysmenorrhea treated by buccal acupuncture therapy: a randomized controlled study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Trial
- An Open Trial of a Mind-Body Intervention for Young Women with Moderate to Severe Primary Dysmenorrhea.Pain medicine (Malden, Mass.) · 2020Trial
- The role of probiotics in improving menstrual health in women with primary dysmenorrhoea: A randomized, double-blind, placebo-controlled trial (the PERIOD study).Women's health (London, England)Trial
- \Stopping Dysmenorrhea: A Systematic Review of Drugs Inhibiting Uterine Contractions.Journal of endometriosis and uterine disorders · 2026Article
- Real-life use of non-pharmacological strategies and their relationship with symptom burden in primary dysmenorrhea: a cross-sectional study.BMC complementary medicine and therapies · 2026Article
- Integrated Pharmacokinetics, Pharmacodynamics, and Pharmacometabolomics to Elucidate Guizhi Fuling Capsule's Homeostatic Mechanism Against Acute Dysmenorrhea.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Nonsteroidal anti-inflammatory drug resistance in dysmenorrhea: a study of prevalence, predictors, and alternative pain management among Nigerian female students.Reproductive health · 2026Article
- Mechanistic insights into inflammatory cytokines in adenomyosis‑induced infertility (Review).International journal of molecular medicine · 2026Review
- The effect of progressive muscle relaxation exercises on primary dysmenorrhea, menstrual symptoms, and quality of life: a randomized controlled trial.Irish journal of medical science · 2026Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although nonsteroidal antiinflammatory drugs can alleviate menstrual pain, about 18% of women with dysmenorrhea are unresponsive, leaving them and their physicians to pursue less well-studied strategies. The goal of this review is to provide a background for treating menstrual pain when first-line options fail. Research on menstrual pain and failure of similar drugs in the antiplatelet category suggested potential mechanisms underlying nonsteroidal antiinflammatory drug resistance. Based on these mechanisms, alternative options may be helpful for refractory cases. This review also identifies key pathways in need of further study to optimize menstrual pain treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.