ReviewMechanisms of development2017
Neural crest and cancer: Divergent travelers on similar paths.
Review in Mechanisms of development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Conservation of Epithelial-to-Mesenchymal Transition Process in Neural Crest Cells and Metastatic Cancer.Cells, tissues, organs · 2021Pooled it
- SNED1 modulates ECM architecture and cell proliferation via its LDV integrin-binding motif.Journal of cell science · 2026Article
- SNED1 modulates ECM architecture and cell proliferation via LDV-binding integrins.bioRxiv : the preprint server for biology · 2026Article
- The novel ECM protein SNED1 mediates cell adhesion via the RGD-binding integrins α5β1 and αvβ3.Journal of cell science · 2025Article
- The effect of chemotherapeutic agents on epidermal neural crest stem cells.Molecular biology research communications · 2025Article
- Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.Pigment cell & melanoma research · 2024Article
- Clinical and Genetic Correlation in Neurocristopathies: Bridging a Precision Medicine Gap.Journal of clinical medicine · 2024Review
- "Beyond transcription: How post-transcriptional mechanisms drive neural crest EMT".Genesis (New York, N.Y. : 2000) · 2024Review
- Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers.Epigenetics & chromatin · 2023Article
- Coordinated regulation of Cdc42ep1, actin, and septin filaments during neural crest cell migration.Frontiers in cell and developmental biology · 2023Article
- Scents from the past: Lineage history and terminal identity in the olfactory system.Natural sciences (Weinheim, Germany) · 2022Article
- Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination.Oncogenesis · 2022Article
- Chick cranial neural crest cells release extracellular vesicles that are critical for their migration.Journal of cell science · 2022Article
- Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model.Nature communications · 2022Article
- KDM5B promotes cell migration by regulating the noncanonical Wnt/PCP pathway in Hirschsprung's disease.Pediatric surgery international · 2022Article
- Neuroblastoma differentiation in vivo excludes cranial tumors.Developmental cell · 2021Article
- Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state.Acta neuropathologica · 2021Article
- Ptk7 Is Dynamically Localized at Neural Crest Cell-Cell Contact Sites and Functions in Contact Inhibition of Locomotion.International journal of molecular sciences · 2021Article
- Roles for growth factors and mutations in metastatic dissemination.Biochemical Society transactions · 2021Review
- Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development.Communications biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Neural crest cells are multipotent progenitors that dynamically interpret diverse microenvironments to migrate significant distances as a loosely associated collective and contribute to many tissues in the developing vertebrate embryo. Uncovering details of neural crest migration has helped to inform a general understanding of collective cell migration, including that which occurs during cancer metastasis. Here, we discuss several commonalities and differences of neural crest and cancer cell migration and behavior. First, we focus on some of the molecular pathways required for the initial specification and potency of neural crest cells and the roles of many of these pathways in cancer progression. We also describe epithelial-to-mesenchymal transition, which plays a critical role in initiating both neural crest migration and cancer metastasis. Finally, we evaluate studies that demonstrate myriad forms of cell-cell and cell-environment communication during neural crest and cancer collective migration to highlight the remarkable similarities in their molecular and cell biological regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.