Observational studyAmerican heart journal2017
Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure.
Observational study in American heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factors associated with non-use and sub-target dosing of medical therapy for heart failure with reduced ejection fraction.Heart failure reviews · 2022Pooled it
- Health Status in Heart Failure With Preserved Ejection Fraction in Asia: Insights From Global Trials.JACC. Asia · 2026Article
- Impact of Race and Ethnicity on Outcomes After Mitral Transcatheter Edge-to-Edge Repair: Analysis From the COAPT Trial.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Comprehensive Introduction to ASIAN-HF Registry.JACC. Asia · 2025Article
- Can Sodium-Glucose Co-Transporter-2 Inhibitors Improve Sleep Quality, Anxiety, and Quality of Life in Patients With Heart Failure?Clinical cardiology · 2025Observational
- Evaluating the Prognostic Value of Kansas City Cardiomyopathy Questionnaire (KCCQ) Scores for 6-Month Readmissions in Southeast Asian Populations With Heart Failure.Clinical cardiology · 2025Article
- Article
- Racial and Ethnic Disparities in Perceived Health Status Among Patients With Cardiovascular Disease.Preventing chronic disease · 2024Article
- Examining health-related quality of life in ambulatory adult patients with chronic heart failure: insights from Malaysia using EQ-5D-5L.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Differences in Health-Related Quality of Life among Patients with Heart Failure.Medicina (Kaunas, Lithuania) · 2024Review
- Patient-Reported Status and Heart Failure Outcomes in Asia by Sex, Ethnicity, and Socioeconomic Status.JACC. Asia · 2023Article
- Primary Disease, Sex, and Racial Differences in Health-Related Quality of Life in Adolescents and Young Adults with Heart Failure.Pediatric cardiology · 2022Article
- Quality of Life in Older Patients after a Heart Failure Hospitalization: Results from the SENECOR Study.Journal of clinical medicine · 2022Article
- Influence of Health Education Based on IMB on Prognosis and Self-Management Behavior of Patients with Chronic Heart Failure.Computational and mathematical methods in medicine · 2022Article
- Prevalence and Prognostic Significance of Frailty in Asian Patients With Heart Failure: Insights From ASIAN-HF.JACC. Asia · 2021Article
- Patient-reported outcomes in heart failure with preserved vs. reduced ejection fraction: focus on physical independence.ESC heart failure · 2020Article
- Factors limiting habitual exercise in patients with chronic heart failure: a multicenter prospective cohort study.Heart and vessels · 2020Article
- Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study.PLoS medicine · 2019Observational
- Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas.European journal of heart failure · 2019Article
- The Utility of 5 Hypothetical Health States in Heart Failure Using Time Trade-Off (TTO) and EQ-5D-5L in Korea.Clinical drug investigation · 2018Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundAssessing health-related quality of life (HRQoL) in patients with heart failure (HF) is an important goal of clinical care and HF research. We sought to investigate ethnic differences in perceived HRQoL and its association with mortality among patients with HF and left ventricular ejection fraction ≤35%, controlling for demographic characteristics and HF severity. METHODS AND
resultsWe compared 5697 chronic HF patients of Indian (26%), white (23%), Chinese (17%), Japanese/Koreans (12%), black (12%), and Malay (10%) ethnicities from the HF-ACTION and ASIAN-HF multinational studies using the Kansas City Cardiomyopathy Questionnaire (KCCQ; range 0-100; higher scores reflect better health status). KCCQ scores were lowest in Malay (58±22) and Chinese (60±23), intermediate in black (64±21) and Indian (65±23), and highest in white (67±20) and Japanese or Korean patients (67±22) after adjusting for age, sex, educational status, HF severity, and risk factors. Self-efficacy, which measures confidence in the ability to manage symptoms, was lower in all Asian ethnicities (especially Japanese/Koreans [60±26], Malay [66±23], and Chinese [64±28]) compared to black (80±21) and white (82±19) patients, even after multivariable adjustment (P<.001). In all ethnicities, KCCQ strongly predicted 1-year mortality (HR 0.45, 95% CI 0.30-0.67 for highest vs lowest quintile of KCCQ; P for interaction by ethnicity .101).
conclusionsOverall, HRQoL is inversely and independently related to mortality in chronic HF but is not modified by ethnicity. Nevertheless, ethnic differences exist independent of HF severity and comorbidities. These data may have important implications for future global clinical HF trials that use patient-reported outcomes as endpoints.
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