ArticleRadiation oncology (London, England)2017
Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients ≥65 years old.
Article in Radiation oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Symptom Clusters in Head and Neck Cancer: A Systematic Review and Conceptual Model.Seminars in oncology nursing · 2021Pooled it
- Effect of Oral Somatosensory Training on Oral Somatosensory Dysfunction in Head and Neck Cancer Survivors.Asian Pacific journal of cancer prevention : APJCP · 2024Trial
- Dyadic Yoga for Head and Neck Cancer Patients Undergoing Chemoradiation and their Family Caregivers.Journal of pain and symptom management · 2024Trial
- L-VISP: LSTM Visualization for Interpretable Symptom Prediction in Patient Cohorts.Computer graphics forum : journal of the European Association for Computer Graphics · 2026Article
- Patient-reported outcomes after ipsilateral radiation therapy for N2b tonsillar squamous cell carcinoma.Discover oncology · 2025Article
- Stiefel MD Anderson OroPharynx cancer (MDA-OPC) cohort: a single-institution, prospective longitudinal outcomes study.BMJ open · 2025Article
- Dual-Attention BiLSTM for Interpretable Forecasting of Treatment Toxicities.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2025Article
- Article
- Designing an Electronic Patient-Reported Outcomes Information Infrastructure Supported by the RE-AIM Implementation Framework.Advances in cancer education and quality improvement · 2025Article
- Investigating Symptom Duration Using Current Status Data: A Case Study of Postacute COVID-19 Syndrome.Epidemiology (Cambridge, Mass.) · 2025Article
- PRO-Based Stratification Improves Model Prediction for Toxicity and Survival of Head and Neck Cancer Patients.IEEE journal of biomedical and health informatics · 2025Article
- Roses Have Thorns: Understanding the Downside of Oncological Care Delivery Through Visual Analytics and Sequential Rule Mining.IEEE transactions on visualization and computer graphics · 2024Article
- Improving Prediction of Late Symptoms using LSTM and Patient-reported Outcomes for Head and Neck Cancer Patients.Proceedings. IEEE International Conference on Healthcare Informatics · 2023Article
- The influence of radiation dose on taste impairment in a prospective observational study cohort of oropharyngeal cancer patients.Acta oncologica (Stockholm, Sweden) · 2022Observational
- THALIS: Human-Machine Analysis of Longitudinal Symptoms in Cancer Therapy.IEEE transactions on visualization and computer graphics · 2022Article
- Predicting late symptoms of head and neck cancer treatment using LSTM and patient reported outcomes.Proceedings. International Database Engineering and Applications Symposium · 2021Article
- Article
- Patient-Reported Outcomes-Guided Adaptive Radiation Therapy for Head and Neck Cancer.Frontiers in oncology · 2021Article
- Symptom Clusters and Quality of Life in Cervical Cancer Patients Receiving Concurrent Chemoradiotherapy: The Mediating Role of Illness Perceptions.Frontiers in psychiatry · 2021Article
- Prospective observational evaluation of radiation-induced late taste impairment kinetics in oropharyngeal cancer patients: Potential for improvement over time?Clinical and translational radiation oncology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
31 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGiven the potential for older patients to experience exaggerated toxicity and symptoms, this study was performed to characterize patient reported outcomes in older patients following definitive radiation therapy (RT) for oropharyngeal cancer (OPC).
methodsCancer-free head and neck cancer survivors (>6 months since treatment completion) were eligible for participation in a questionnaire-based study. Participants completed the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). Those patients ≥65 years old at treatment for OPC with definitive RT were included. Individual and overall symptom severity and clinical variables were analyzed.
resultsOf the 79 participants analyzed, 82% were male, 95% white, 41% T3/4 disease, 39% RT alone, 27% induction chemotherapy, 52% concurrent, and 18% both, and 96% IMRT. Median age at RT was 71 yrs. (range: 65-85); median time from RT to MDASI-HN was 46 mos. (2/3 > 24 mos.). The top 5 MDASI-HN items rated most severe in terms of mean (±SD) ratings (0-10 scale) were dry mouth (3.48 ± 2.95), taste (2.81 ± 3.29), swallowing (2.59 ± 2.96), mucus in mouth/throat (2.04 ± 2.68), and choking (1.30 ± 2.38) reported at moderate-severe levels (≥5) by 35, 29, 29, 18, and 13%, respectively. Thirty-nine % reported none (0) or no more than mild (1-4) symptoms across all 22 MDASI-HN symptoms items, and 38% had at least one item rated as severe (≥7). Hierarchical cluster analysis resulted in 3 patient groups: 1) ~65% with ranging from none to moderate symptom burden, 2) ~35% with moderate-severe ratings for a subset of classically RT-related symptoms (e.g. dry mouth, mucus, swallowing) and 3) 2 pts. with severe ratings of most items.
conclusionsThe overall long-term symptom burden seen in this older OPC cohort treated with modern standard therapy was largely favorable, yet a higher symptom group (~35%) with a distinct pattern of mostly local and classically RT-related symptoms was identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.