ArticleThe European journal of neuroscience2017
The anterior insula bidirectionally modulates cost-benefit decision-making on a rodent gambling task.
Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neuronal architecture of the mouse insular cortex underlying its diverse functions.bioRxiv : the preprint server for biology · 2025Article
- Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function.iScience · 2025Review
- Article
- Exploring rodent prosociality: A conceptual framework.Translational neuroscience · 2025Review
- Interoceptive Processing in Substance Use Disorders (SUDs): From the Neuroanatomy to Insights from Computational Models and Predictive Coding Frameworks.Current topics in behavioral neurosciences · 2025Review
- Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats.International journal of molecular sciences · 2024Article
- Still a "hidden island"? The rodent insular cortex in drug seeking, reward, and risk.Neuroscience and biobehavioral reviews · 2023Review
- Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking.Addiction neuroscience · 2023Article
- Atypical interoception as a common risk factor for psychopathology: A review.Neuroscience and biobehavioral reviews · 2021Review
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
- Stimulation in the Rat Anterior Insula and Anterior Cingulate During an Effortful Weightlifting Task.Frontiers in neuroscience · 2021Article
- Chronic Distress in Male Mice Impairs Motivation Compromising Both Effort and Reward Processing With Altered Anterior Insular Cortex and Basolateral Amygdala Neural Activation.Frontiers in behavioral neuroscience · 2021Article
- Prolonged avoidance training exacerbates OCD-like behaviors in a rodent model.Translational psychiatry · 2020Article
- Impaired decision making following escalation of cocaine self-administration predicts vulnerability to relapse in rats.Addiction biology · 2020Article
- Compulsive Alcohol Seeking Results from a Failure to Disengage Dorsolateral Striatal Control over Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Understanding Addiction Using Animal Models.Frontiers in behavioral neuroscience · 2019Article
- Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
Deficits in cost-benefit decision-making, as assessed in the Iowa Gambling Task (IGT), are commonly observed in neuropsychiatric disorders such as addiction. There is considerable variation in the maximization of rewards on such tasks, both in the general population and in rodent models, suggesting individual differences in decision-making may represent a key endophenotype for vulnerability to neuropsychiatric disorders. Increasing evidence suggests that the insular cortex, which is involved in interoception and emotional processes in humans, may be a key neural locus in the control of decision-making processes. However, the extent to which the insula contributes to individual differences in cost-benefit decision-making remains unknown. Using male Sprague Dawley rats, we first assessed individual differences in the performance over the course of a single session on a rodent analogue of the IGT (rGT). Rats were matched for their ability to maximize reward and received bilateral excitotoxic or sham lesions of the anterior insula cortex (AIC). Animals were subsequently challenged on a second rGT session with altered contingencies. Finally, animals were also assessed for instrumental conditioning and reversal learning. AIC lesions produced bidirectional alterations on rGT performance; rats that had performed optimally prior to surgery subsequently showed impairments, and animals that had performed poorly showed improvements in comparison with sham-operated controls. These bidirectional effects were not attributable to alterations in behavioural flexibility or in motivation. These data suggest that the recruitment of the AIC during decision-making may be state-dependent and help guide response selection towards subjectively favourable options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.