ArticleJournal of veterinary internal medicine2017
Opportunistic Invasive Cutaneous Fungal Infections Associated with Administration of Cyclosporine to Dogs with Immune-mediated Disease.
Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Cutaneous Invasive Opportunistic Fungal Infections in Dogs Receiving Ciclosporin for Immune-Mediated Diseases: A Case-Control Study.Veterinary dermatology · 2026Article
- Ex vivo effects of oclacitinib and cyclosporin A on canine immune response to Leishmania infantum.Scientific reports · 2026Article
- Deep Fungal Infection of the Skin with Two Rare Fungi in a Dog Being Treated with Immunosuppressant Therapy: A Case Report.Veterinary sciences · 2025Article
- Case report: Clinical fungal endocarditis as a component of presumptive systemic aspergillosis infection in a dog.Frontiers in veterinary science · 2025Article
- DisseminatedClinical case reports · 2024Article
- Mycophenolate mofetil as a treatment for presumed idiopathic chronic hepatitis in dogs: Six cases (2010-2022).Veterinary medicine and science · 2023Article
- Investigation of the therapeutic effects, predictors, and complications of long-term immunosuppressive therapy in dogs with precursor-targeted immune-mediated anemia.The Journal of veterinary medical science · 2023Article
- Article
- Perspectives on pharmacologic strategies in the management of meningoencephalomyelitis of unknown origin in dogs.Frontiers in veterinary science · 2023Review
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Review
- Presumptive hemophagocytic syndrome associated with immune-mediated anemia in two Miniature Dachshunds.The Journal of veterinary medical science · 2021Article
- Neutropenia in dogs receiving vincristine for treatment of presumptive immune-mediated thrombocytopenia.Journal of veterinary internal medicine · 2021Article
- Effect of dilution of canine blood samples on the specificity of saline agglutination tests for immune-mediated hemolysis.Journal of veterinary internal medicine · 2020Article
- Recovery of T-cell function in healthy dogs following cessation of oral cyclosporine administration.Veterinary medicine and science · 2020Article
- Retrospective evaluation of cyclosporine in the treatment of presumed idiopathic chronic hepatitis in dogs.Journal of veterinary internal medicine · 2019Article
- ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs.Journal of veterinary internal medicine · 2019Article
- Risk factors for Candida urinary tract infections in dogs and cats.Journal of veterinary internal medicine · 2019Article
- Successful Treatment of CutaneousFrontiers in veterinary science · 2019Article
- ACVIM consensus statement on the treatment of immune thrombocytopenia in dogs and cats.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpportunistic invasive fungal infections (OIFIs) occur in dogs administered immunosuppressive medications. However, the epidemiology of OIFIs among dogs undergoing immunosuppressive treatment is poorly understood. The aims of this study were to (1) estimate the incidence of OIFIs among dogs diagnosed with certain immune-mediated diseases and treated with immunosuppressive drugs, and (2) determine if administration of particular drug(s) was a risk factor for OIFIs. HYPOTHESIS: Dogs receiving cyclosporine treatment (alone or as part of a multidrug protocol) are at higher risk of developing OIFIs. ANIMALS: One hundred and thirteen client-owned dogs diagnosed with select immune-mediated diseases: 42 with IMHA, 29 with ITP, 34 with IMPA, and 8 with Evans syndrome.
methodsRetrospective cohort study. Medical records of dogs presenting to the Texas A&M University, Veterinary Medical Teaching Hospital between January 2008 and December 2015, and treated for 1 or more of IMHA, IMPA, ITP, or Evans syndrome were retrospectively reviewed. Dogs that did not develop an OIFI were excluded if they died, were euthanized, or were lost to follow-up within 120 days of initiation of immunosuppressive treatment.
resultsFifteen dogs of 113 (13%) were diagnosed with an OIFI based on 1 or more of cytology, culture, or histopathology. The odds of developing an OIFI were greater among dogs that were treated with cyclosporine (OR = 7.1, P = 0.017; 95% CI, 1.5-34.4) and among male dogs (OR = 5.1, P = 0.018; 95% CI, 1.4-17.9). CONCLUSIONS AND CLINICAL IMPORTANCE: OIFIs were significantly more likely in male dogs and those receiving cyclosporine. It is important to consider OIFIs as a potential complication of immunosuppressive treatment, particularly cyclosporine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.