ArticleInternational journal of computer assisted radiology and surgery2018
A novel integration of spectral-domain optical-coherence-tomography and laser-ablation system for precision treatment.
Article in International journal of computer assisted radiology and surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Precise ablation of cholesteatoma using a 445-nm diode laser.Scientific reports · 2026Article
- Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.Theranostics · 2025Review
- The State-of-the-Art and Perspectives of Laser Ablation for Tumor Treatment.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- The LMIT: Light-mediated minimally-invasive theranostics in oncology.Theranostics · 2024Review
- Real-time closed-loop tissue-specific laser osteotomy using deep-learning-assisted optical coherence tomography.Biomedical optics express · 2023Article
- N-mirror Robot System for Laser Surgery: A Simulation Study.... International Symposium on Medical Robotics. International Symposium on Medical Robotics · 2023Article
- Towards OCT-Guided Endoscopic Laser Surgery-A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions.Lasers in medical science · 2022Article
- Intelligent optical diagnosis and treatment system for automated image-guided laser ablation of tumors.International journal of computer assisted radiology and surgery · 2021Article
- Long-range optical coherence tomography with extended depth-of-focus: a visual feedback system for smart laser osteotomy.Biomedical optics express · 2021Article
- Laser brain cancer surgery in a xenograft model guided by optical coherence tomography.Theranostics · 2019Article
- Can "Indirect" Contact Laser Surgery be Used for Fluorescence-Image Guided Tumor Resections? Preliminary Results.Technology in cancer research & treatment · 2018Article
- Bioluminescence imaging and two-photon microscopy guided laser ablation of GBM decreases tumor burden.Theranostics · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeComplete resection of diseased lesions reduces the recurrence of cancer, making it critical for surgical treatment. However, precisely resecting residual tumors is a challenge during operation. A novel integrated spectral-domain optical-coherence-tomography (SD-OCT) and laser-ablation therapy system for soft-biological-tissue resection is proposed. This is a prototype optical integrated diagnosis and therapeutic system as well as an optical theranostics system.
methodsWe develop an optical theranostics system, which integrates SD-OCT, a laser-ablation unit, and an automatic scanning platform. The SD-OCT image of biological tissue provides an intuitive and clear view for intraoperative diagnosis and monitoring in real time. The effect of laser ablation is analyzed using a quantitative mathematical model. The automatic endoscopic scanning platform combines an endoscopic probe and an SD-OCT sample arm to provide optical theranostic scanning motion. An optical fiber and a charge-coupled device camera are integrated into the endoscopic probe, allowing detection and coupling of the OCT-aiming beam and laser spots.
resultsThe integrated diagnostic and therapeutic system combines SD-OCT imaging and laser-ablation modules with an automatic scanning platform. OCT imaging, laser-ablation treatment, and the integration and control of diagnostic and therapeutic procedures were evaluated by performing phantom experiments. Furthermore, SD-OCT-guided laser ablation provided precision laser ablation and resection for the malignant lesions in soft-biological-tissue-lesion surgery. The results demonstrated that the appropriate laser-radiation power and duration time were 10 W and 10 s, respectively. In the laser-ablation evaluation experiment, the error reached approximately 0.1 mm. Another validation experiment was performed to obtain OCT images of the pre- and post-ablated craters of ex vivo porcine brainstem.
conclusionWe propose an optical integrated diagnosis and therapeutic system. The primary experimental results show the high efficiency and feasibility of our theranostics system, which is promising for realizing accurate resection of tumors in vivo and in situ in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.