SynthesisSports medicine (Auckland, N.Z.)2018
Factors Contributing to Chronic Ankle Instability: A Systematic Review and Meta-Analysis of Systematic Reviews.
Synthesis in Sports medicine (Auckland, N.Z.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 19 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 19 syntheses or guidelines pooled it.
- Effects of blood-flow restriction training on dynamic postural control and ankle function in individuals with chronic ankle instability: a systematic review and meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2026Pooled it
- Effects of exercise therapy on dynamic posture control and self-report function in individuals with chronic ankle instability: a systematic review with pairwise and network meta-analysis.EFORT open reviews · 2026Pooled it
- Is Kinesio taping an effective approach for acute ankle sprains? A systematic review and meta-analysis.EFORT open reviews · 2026Pooled it
- Does transcranial direct current stimulation enhance sensorimotor recovery in chronic ankle instability? A systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Alterations in corticospinal excitability in individuals with ankle sprains: a systematic review of transcranial magnetic stimulation studies.Frontiers in physiology · 2026Pooled it
- Virtual reality-based interventions enhance functional status, balance and muscle strength in patients with ankle instability: a systematic review with meta-analysis of randomized controlled trials.European journal of physical and rehabilitation medicine · 2025Pooled it
- Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Can exercise therapy combined with transcranial direct current stimulation further improve balance ability in individuals with chronic ankle instability? A systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Which therapeutic exercise is most effective for improving ankle inversion muscle function in individuals with chronic ankle instability? A systematic review and network meta-analysis.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Bilateral Sensorimotor Impairments in Individuals with Unilateral Chronic Ankle Instability: A Systematic Review and Meta-Analysis.Sports medicine - open · 2024Pooled it
- The effect of movement representation techniques on ankle function and performance in persons with or without a lateral ankle sprain: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2023Pooled it
- Brain Neuroplasticity Related to Lateral Ankle Ligamentous Injuries: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Technical aspects of virtual augmented reality-based rehabilitation systems for musculoskeletal disorders of the lower limbs: a systematic review.BMC musculoskeletal disorders · 2023Pooled it
- Effects of plantar-sensory treatments on postural control in chronic ankle instability: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Is Postural Control Affected in People with Patellofemoral Pain and Should it be Part of Rehabilitation? A Systematic Review with Meta-analysis.Sports medicine - open · 2022Pooled it
- Is Kinesio Taping Effective for Sport Performance and Ankle Function of Athletes with Chronic Ankle Instability (CAI)? A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Predictors of Persistent Participation in Youth Sport: A Systematic Review and Meta-Analysis.Frontiers in psychology · 2022Pooled it
- Chronic ankle instability is associated with proprioception deficits: A systematic review and meta-analysis.Journal of sport and health science · 2021Pooled it
- Pooled it
- Trial
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany factors are thought to contribute to chronic ankle instability (CAI). Multiple systematic reviews have synthesised the available evidence to identify the primary contributing factors. However, readers are now faced with several systematic reviews that present conflicting findings.
objectiveThe aim of this systematic review and meta-analysis was to establish the statistical significance and effect size of primary factors contributing to CAI and to identify likely reasons for inconsistencies in the literature.
methodsRelevant health databases were searched: CINAHL, MEDLINE, PubMed, Scopus and SPORTDiscus. Systematic reviews were included if they answered a focused research question, clearly defined the search strategy criteria and study selection/inclusion and completed a comprehensive search of the literature. Included reviews needed to be published in a peer-reviewed journal and needed to review observational studies of factors and/or characteristics of persons with CAI, with or without meta-analysis. There was no language restriction. Studies using a non-systematic review methodology (e.g. primary studies and narrative reviews) were excluded. Methodological quality of systematic reviews was assessed using the modified R-AMSTAR tool. Meta-analysis on included primary studies was performed.
resultsOnly 17% of primary studies measured a clearly defined CAI population. There is strong evidence to support the contribution of dynamic balance, peroneal reaction time and eversion strength deficits and moderate evidence for proprioception and static balance deficits to non-specific ankle instability.
conclusionsEvidence from previous systematic reviews does not accurately reflect the CAI population. For treatment of non-specific ankle instability, clinicians should focus on dynamic balance, reaction time and strength deficits; however, these findings may not be translated to the CAI population. Research should be updated with an adequately controlled CAI population. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 2016, CRD42016032592.
Indexed as
Identifiers
28887759What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.