Evidence map›Paper›PMID 28887755›Full record

ReviewCurrent gastroenterology reports2017

Prokinetics in the Management of Functional Gastrointestinal Disorders.

Eamonn M M Quigley

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current gastroenterology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04104867 (A Randomized Controlled Double-blinded of Effectiveness of Prokinetic Agents in Improving Abdominal Discomfort at Pre- and Post- Colonoscopy), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04104867 naunknown statusnot on this mapstarted 2019, after this paper: background citation

A Randomized Controlled Double-blinded of Effectiveness of Prokinetic Agents in Improving Abdominal Discomfort at Pre- and Post- Colonoscopy

TypeinterventionalSponsorMahidol UniversityRan2019 to 2023Enrolled525ConditionsAbdominal PainArmsItopride, Domperidone, Placebo
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
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  4. Review
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  8. Article
  9. Review
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  12. Review
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  14. Article
  15. Non-pharmacological Approach in the Management of Functional Dyspepsia.Journal of neurogastroenterology and motility · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Eamonn M M QuigleyLynda K and David M Underwood Center for Digestive Disorders, Houston, TX, USA. equigley@houstonmethodist.org.
Methodist Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe goal of this review is to review the current status of prokinetics and to place it in historical context. Impaired motility and thus propulsion have long been thought to play important roles in the pathogenesis of a number of gastrointestinal disorders including gastroesophageal reflux disease (GERD), gastroparesis, chronic idiopathic pseudo-obstruction, and constipation. Historically, disordered motility was also thought to contribute to a number of functional gastrointestinal disorders such as functional dyspepsia (FD) and irritable bowel syndrome (IBS). RECENT

findingsAs we learn more of the pathophysiology of FD, IBS, GERD, constipation, and gastroparesis, the limitations of a therapeutic strategy based on the stimulation of motility (i.e., the use of a prokinetic) have become apparent and the disappointments of the past explained. The development of prokinetic drugs has also been hampered by the non-selective nature of many of the agents studied to date which resulted in some unexpected side effects. There is still an unmet need for an effective and safe prokinetic, but drug development in this area must be mindful of the challenges of the area and the need for selectivity for a given target receptor.

Indexed as

ConstipationDyspepsiaGastroesophageal RefluxGastrointestinal AgentsGastrointestinal DiseasesGastrointestinal MotilityGastroparesisHumansIrritable Bowel SyndromeGastrointestinal Agents5-HydroxytryptamineAcetylcholineConstipationFunctional gastrointestinal disordersGastroparesisIrritable bowel syndromeMotilinMotilityProkineticSerotonin

Identifiers

PMID28887755
OpenAlexW2755293342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.