SynthesisJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2017
Efficacy of ganglionated plexi ablation in addition to pulmonary vein isolation for paroxysmal versus persistent atrial fibrillation: a meta-analysis of randomized controlled clinical trials.
Synthesis in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03636100 (Systemic Release of Acetylcholine From the Autonomic Ganglionated Plexus), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systemic Release of Acetylcholine From the Autonomic Ganglionated Plexus: a Proposed Mechanism of Induced Hypotension During the Thaw Phase of Cryoballon Pulmonary Vein Ablation (GP RESPONSE Study)
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pulmonary vein isolation plus adjunctive therapy for the treatment of atrial fibrillation: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Pooled it
- Preventing atrial fibrillation recurrence with combination of catheter ablation and renal denervation or ganglion plexus ablation: A systematic review and network meta-analysis.Indian heart journalPooled it
- Swallowing Syncope With Atrial Fibrillation Treated by Wide Area Circumferential Ablation and Cardioneuroablation.JACC. Case reports · 2026Article
- Pulsed field ablation vs. medical therapy for atrial fibrillation: a propensity score-matched comparison with the JoFib registry.Frontiers in cardiovascular medicine · 2026Article
- Maintenance of atrial fibrillation by reciprocal triggering of competitive focal sources: a hypothesis.Frontiers in cardiovascular medicine · 2026Review
- Brazilian Atrial Fibrillation Guidelines - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Ganglionated plexi ablation impact on atrial fibrillation mechanisms and outcomes in patients with low scar burden.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia Treatment.Biomedicines · 2025Review
- Effects of Pulmonary Vein Isolation for Atrial Fibrillation on Skin Sympathetic Nerve Activity in Association with Left Atrial Remodeling.Journal of cardiovascular development and disease · 2025Article
- Strategies for Recurrent Atrial Fibrillation in Patients Despite Durable Pulmonary Vein Isolation.Journal of clinical medicine · 2025Article
- Vagal AF induction test (VAFIT): a new endpoint for optimizing atrial fibrillation ablation through cardioneuroablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Review
- Short-term deceleration capacity: a novel non-invasive indicator of parasympathetic activity in patients undergoing pulmonary vein isolation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- AFTER-CA: Autonomic Function Transformation and Evaluation Following Catheter Ablation in Atrial Fibrillation.Journal of clinical medicine · 2024Article
- Atrial Fibrillation and Underlying Structural and Electrophysiological Heterogeneity.International journal of molecular sciences · 2024Review
- Development of neuromodulation for atrial fibrillation: a narrative review.Journal of thoracic disease · 2024Review
- Observational
- The Intrinsic Cardiac Nervous System: From Pathophysiology to Therapeutic Implications.Biology · 2024Review
- Transcatheter options for atrial fibrillation treatment: an overview of the ablative techniques currently available and future perspectives.Annals of cardiothoracic surgery · 2024Review
- Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation.Journal of cardiovascular development and disease · 2023Review
- Ripple Frequency Determined via a Novel Algorithm Is Associated With Atrial Fibrillation Termination and Freedom From Atrial Fibrillation.Heart rhythm O2 · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdjunctive ganglionated plexi (GP) ablation may improve success rates for treatment of atrial fibrillation (AF) when combined with pulmonary vein (PV) isolation. Existing meta-analyses on GP ablation have included observational studies and have not incorporated more recent randomized clinical trial data. Moreover, the impact of AF subtype (paroxysmal vs. persistent) on outcomes of GP ablation has not been well established.
methodsWe performed a meta-analysis of randomized controlled trials (RCTs) comparing GP ablation + pulmonary vein (PV) isolation versus PV isolation alone according to the subtype of AF. The primary endpoint was freedom from sustained AF or atrial tachyarrhythmia (AT) after a single procedure.
resultsAcross four RCTs, 718 patients (358 and 360 that underwent GP ablation + PV isolation [intervention] vs. PV isolation alone [control], respectively) were included in the study. Mean left atrial size and left ventricular ejection fraction were 45.7 mm and 54.8%, respectively. Among paroxysmal AF patients, GP ablation was linked to significantly higher freedom from AT/AF (75.8 vs. 60.0% for the intervention vs. control arms respectively; OR [95% CI]: 2.22 [1.36-3.61], P = 0.001). Among persistent AF patients, GP ablation was associated with a non-significant trend towards higher rates of freedom from AT/AF (54.7 vs. 43.3% for the intervention vs. control arms respectively; OR [95% CI]: 1.55 [0.96-2.52], P = 0.08). In all cases, heterogeneity was found to be low (I
conclusionsCompared to PV isolation alone, GP ablation + PV isolation is associated with better outcomes in patients with paroxysmal AF and without significant structural heart disease.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.