Evidence map›Paper›PMID 28887720›Full record

ArticleMaternal and child health journal2018

Early Folic Acid Supplement Initiation and Risk of Adverse Early Childhood Respiratory Health: A Population-based Study.

Vivian H Alfonso, Gretchen Bandoli, Ondine von Ehrenstein, Beate Ritz

Abstract read
PubMed Publisher
In one paragraph

Article in Maternal and child health journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Periconceptional folic acid supplementation and child asthma: aThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022
    Article
  8. S3 guideline Allergy Prevention.Allergologie select · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vivian H AlfonsoDepartment of Epidemiology, University of California, Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA, 90095, USA. vivianhelena@ucla.edu.
Gretchen BandoliDepartment of Epidemiology, University of California, Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA, 90095, USA.
Ondine von EhrensteinDepartment of Community Health Sciences, University of California, Los Angeles, 650 Charles E Young Drive S, Los Angeles, CA, 90095, USA.
Beate RitzDepartment of Epidemiology, University of California, Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · US

Funding

Air Pollution and Adverse Birth OutcomesR01ES010960 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R · 2001 to 2004
$921k
Ambient Air Toxics and Adverse Birth OutcomesR03ES017119 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TURNER, MICHELLE WILHELM · 2009 to 2010
$143k
NIEHS NIH HHS R01ES010960-01NIEHS NIH HHS R03ES017119-01
6 · The paper itself

Abstract

Objectives Folate plays a vital role in biologic functions yet women often do not meet the recommended dietary intake in pregnancy. It has been suggested that high folic acid intake during pregnancy may increase the risk of respiratory diseases in offspring. However, findings from observational studies in human populations are inconclusive. Methods In this population-based study, we collected self-reported folic acid and prenatal vitamin supplement use during pregnancy 3-6 months postpartum from mothers in Los Angeles whose children were born in 2003. Supplement initiation was based on whichever supplement, either folic acid or prenatal supplements, the women initiated first. In a 2006 follow-up survey, approximately 50% of women were re-contacted to gather information on the child's respiratory health, including symptoms and diagnoses, at approximately 3.5 years of age. Results Overall, timing of folic acid supplement initiation was not associated with wheeze or lower respiratory tract infection, even after accounting for preterm births and censoring at follow-up. However, children born to mothers with a history of atopy (hay fever, eczema or asthma) who initiate folic acid supplements in late pregnancy, compared to first trimester initiators, have 1.67 (95% CI 1.12, 2.49) times the risk of wheeze in the first 3 years of life and 1.88 (95% CI 1.05, 3.34) times the risk of wheeze in the past year. No association was found among children of non-atopic mothers. Conclusions These findings suggest that early folic acid or prenatal supplementation among atopic women may be important to prevent wheeze among offspring.

Indexed as

Dietary SupplementsAdultAsthmaChildChild, PreschoolFemaleFolic AcidHealth SurveysHumansMalePopulation SurveillancePregnancyPregnancy Trimester, FirstPrenatal CarePrenatal Exposure Delayed EffectsRespiratory HypersensitivityFolic AcidChildhood asthmaFolic acidPregnancy and nutritionPrenatal nutritionPrenatal supplementRespiratory health

Identifiers

PMID28887720
OpenAlexW2754311888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.