ArticleMolecular and cellular biochemistry2018
Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging.
Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The neuroprotective effects of melatonin against diabetic neuropathy: A systematic review of non-clinical studies.Frontiers in pharmacology · 2022Pooled it
- Molecular and Biochemical Evidence of Edaravone's Impact on Dasatinib-induced AGS Cell Senescence: A Promising Strategy for Gastric Cancer Therapy.Current medicinal chemistry · 2026Article
- Oenological tannins mitigate rotenone-induced mitochondrial impairments and oxidative stress, with concomitant detection of urolithin A in the brain.Biochemistry and biophysics reports · 2025Article
- Ellagic Acid Mediates the Delay of Dermal Fibroblast Senescence via CSNK2A1.Clinical, cosmetic and investigational dermatology · 2025Article
- Review
- Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest.Frontiers in pharmacology · 2022Article
- Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo.Journal of radiation research · 2021Article
- Impact of Acrylamide on Cellular Senescence Response and Cell Cycle Distribution via an In-vitro Study.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Toxic potential of botulinum toxin type A on senescence in aToxicology reports · 2021Article
- RETRACTED: Therapeutic Effects of Gallic Acid in Regulating Senescence and Diabetes; an In Vitro Study.Molecules (Basel, Switzerland) · 2020Article
- Ellagic acid prolongs the lifespan of Drosophila melanogaster.GeroScience · 2020Article
- Improvement of the functionality of pancreatic Langerhans islets via reduction of bacterial contamination and apoptosis using phenolic compounds.Iranian journal of basic medical sciences · 2018Article
- Biochemical analytes in centrifuged blood samples could be affected by the age of subjects in different time periods and storage temperatures.Asian journal of transfusion scienceArticle
- Protective effect of ellagic acid against high-glucose-induced injury in human umbilical venous endothelial cells.Avicenna journal of phytomedicineArticle
Corrections and comments
- Retraction · 2025-03-27Concerns/Issues about Image · Duplication of/in Image · Euphemisms for Duplication · Investigation by Journal/Publisher · Investigation by Third Party · Objections by Author(s) · Unreliable Image · Unreliable Results and/or Conclusions · · See also: https://pubpeer.com/publications/BC9AB1C3261EC559C6019B6162BD63
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Aging is a natural process in living organisms that is defined by some molecular and cellular changes with time. Various causes such as mitochondrial DNA aberrations, aggregation of proteins, telomere shortening, and oxidative stress have an influential role in aging of the cells. Natural antioxidants are compounds that are potent to protect the body from detrimental effects of molecules such as free radicals. The aim of this study was to evaluate the anti-aging properties of ellagic acid (EA) and silybin (SIL), as natural antioxidant compounds on rat embryonic fibroblast (REF) cells. These cells were pre-incubated with EA and SIL, thereafter were exposed to hydrogen peroxide (H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.