Evidence map›Paper›PMID 28887683›Full record

ReviewStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2018

Lethal outcome after pelvic salvage radiotherapy in a patient with prostate cancer due to increased radiosensitivity : Case report and literature review.

Antje Fahrig, T Koch, M Lenhart, P Rieckmann, R Fietkau, Luitpold Distel, B Schuster

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antje FahrigKlinik und Praxis für Radioonkologie und Strahlentherapie, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany. antje.fahrig@sozialstiftung-bamberg.de.
T KochKlinik und Praxis für Radioonkologie und Strahlentherapie, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany.
M LenhartKlinik für Diagnostische Radiologie, Interventionelle Radiologie und Neuroradiologie, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany.
P RieckmannNeurologische Klinik, Klinikum Bamberg, Sozialstiftung Bamberg, Buger Straße 80, 96049, Bamberg, Germany.
R FietkauStrahlenklinik, Universitätsklinikum Erlangen, Universitätsstraße 27, 91054, Erlangen, Germany.
Luitpold DistelStrahlenklinik, Universitätsklinikum Erlangen, Universitätsstraße 27, 91054, Erlangen, Germany.
B SchusterStrahlenklinik, Universitätsklinikum Erlangen, Universitätsstraße 27, 91054, Erlangen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn general, late side effects after salvage radiotherapy (RT) for prostate cancer are below 10%. Patients with impaired DNA repair ability and genetic instability can have significantly increased reactions after RT. CASE, CLINICAL FOLLOW-UP, AND EXAMINATION: We present a patient who experienced severe side effects after additive RT for prostate cancer and died from the complications 25 months after RT. Imaging (MR) is shown as well as three-color fluorescence in situ hybridization. The blood sample testing revealed that radiosensitivity was increased by 35-55%. We undertook a review of the literature to give an overview over the tests established that are currently considered useful.

conclusionThis case highlights that the identification of patients with increased radiosensitivity is an important task in radiation protection. Groups of patients who should be screened have to be found and corresponding research facilities have to be set up.

Indexed as

Radiation ToleranceAdultAgedAged, 80 and overCombined Modality TherapyFatal OutcomeFemaleHumansMaleMiddle AgedNeoplasm GradingNeoplasm StagingPelvisProstatectomyProstatic NeoplasmsRadiation InjuriesDNA repairFluorescence in situ hybridizationRadiation protectionRadiation toxicityRadiosensitivity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.