Evidence map›Paper›PMID 28887602›Full record

ArticleMedical molecular morphology2018

Correlation between immunohistochemical staining of CEACAM1 and clinicopathological findings in oral pre-neoplastic lesions and squamous cell carcinoma.

Oriana Simonetti, Guendalina Lucarini, Corrado Rubini, Antonio Zizzi, Simone Domenico Aspriello, Roberto Di Primio, Anna Maria Offidani

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Article in Medical molecular morphology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  5. Type IV secretion ofGut pathogens · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Oriana SimonettiDepartment of Dermatology, Polytechnic University of Marche, Torrette, Ancona, Italy.
Guendalina LucariniDepartment of Clinic and Molecular Sciences, Histology, Polytechnic University of Marche, Via Tronto 10/a, Torrette, 60020, Ancona, Italy. guendalina.lucarini@univpm.it.ORCID http://orcid.org/0000-0003-3218-5620
Corrado RubiniDepartment of Biomedical Sciences and Public Health, Section of Pathologic Anatomy and Histopathology, Polytechnic University of Marche, Torrette, Ancona, Italy.
Antonio ZizziDepartment of Biomedical Sciences and Public Health, Section of Pathologic Anatomy and Histopathology, Polytechnic University of Marche, Torrette, Ancona, Italy.
Simone Domenico AsprielloDental Clinic Private Practice, Pesaro, Italy.
Roberto Di PrimioDepartment of Clinic and Molecular Sciences, Histology, Polytechnic University of Marche, Via Tronto 10/a, Torrette, 60020, Ancona, Italy.
Anna Maria OffidaniDepartment of Dermatology, Polytechnic University of Marche, Torrette, Ancona, Italy.
Marche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Squamous cell carcinoma of the oral cavity represents the sixth most common cancer worldwide and it is often preceded by pre-neoplastic lesions. Sometimes it is still difficult for pathologists to make objective differential diagnoses only on histological characteristics. Tumorigenesis is accompanied by altered expression of cell adhesion molecules, like carcinoembryonic antigen cell adhesion molecule (CEACAM)1. We wanted to investigative CEACAM1 in oral dysplastic lesions, carcinoma in situ (CIS) and oral squamous cell carcinoma (OSCC). We examined immunohistochemical CEACAM1 expression in 50 OSCC, 30 oral CIS and 40 pre-neoplastic lesions and assessed its correlation with clinical and pathological parameters. CEACAM1 was not expressed in normal mucosa, significantly expressed in CIS while it was negative in all the dysplastic lesions. In OSCC, high CEACAM1 expression was associated with tumor grade and inversely correlated with both overall and disease-specific 5-year survival. We showed that CEACAM1 expression is very dynamic: absent in dysplastic lesions, up-regulated in CIS and OSCC. We suggest that CEACAM1 could be a prognostic marker of OSCC and oral CIS. Our most important finding was that it could help pathologists diagnosing oral carcinoma in situ.

Indexed as

AdultAgedAged, 80 and overAntigens, CDBiomarkers, TumorCarcinoma in SituCarcinoma, Squamous CellCell Adhesion MoleculesDisease-Free SurvivalFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMiddle AgedMouthAntigens, CDBiomarkers, TumorCD66 antigensCell Adhesion MoleculesCEACAM1ImmunohistochemistryOral pre-neoplastic lesionOral squamous cell carcinomaPrognostic marker

Identifiers

PMID28887602
OpenAlexW2755497735

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.