ArticleScientific reports2017
The salivary microbiome is consistent between subjects and resistant to impacts of short-term hospitalization.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Influence of the long-term use of oral hygiene products containing stannous ions on the salivary microbiome - a randomized controlled trial.Scientific reports · 2020Trial
- The diversity of factors influencing human digestive microbiota in healthy adults and their interaction: a scoping review.BMC nutrition · 2026Article
- Characterization of the oral microbiome in the diverse South African population by PacBio HiFi sequencing.Applied microbiology and biotechnology · 2026Article
- Oral Microbiome Changes During Hospitalization in Older Adults Not Receiving Mechanical Ventilation.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2025Observational
- Saliva assay: a call for methodological standardization.Journal of periodontal & implant science · 2025Review
- The Salivary Microbiome and Predicted Metabolite Production Are Associated with Barrett's Esophagus and High-Grade Dysplasia or Adenocarcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Comparative Analysis of Primers Used for 16S rRNA Gene Sequencing in Oral Microbiome Studies.Methods and protocols · 2023Article
- Screening of heat-killed lactic acid bacteria based on inhibitory activity against oral bacteria and effects of oral administration of heat-killedJournal of oral microbiology · 2023Article
- Dysbiosis in Head and Neck Cancer: Determining Optimal Sampling Site for Oral Microbiome Collection.Pathogens (Basel, Switzerland) · 2022Article
- Choice of 16S Ribosomal RNA Primers Impacts Male Urinary Microbiota Profiling.Frontiers in cellular and infection microbiology · 2022Article
- Minimal Associations between Short-Term Dietary Intake and Salivary Microbiome Composition.Microorganisms · 2021Article
- Quantifying Live Microbial Load in Human Saliva Samples over Time Reveals Stable Composition and Dynamic Load.mSystems · 2021Article
- Increasing Reproducibility in Oral Microbiome Research.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Comparison of Microbiome in Stimulated Saliva in Edentulous and Dentate Subjects.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Salivary microbiome composition changes after bariatric surgery.Scientific reports · 2020Article
- Impact of Diabetes on the Gut and Salivary IgA Microbiomes.Infection and immunity · 2020Article
- Mechanism of Candida pathogenesis: revisiting the vital drivers.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
- Profiling of Oral Bacterial Communities.Journal of dental research · 2020Review
- Optimizing 16S rRNA gene profile analysis from low biomass nasopharyngeal and induced sputum specimens.BMC microbiology · 2020Article
- Profiling the Salivary microbiome of the Qatari population.Journal of translational medicine · 2020Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
In recent years, a growing amount of research has begun to focus on the oral microbiome due to its links with health and systemic disease. The oral microbiome has numerous advantages that make it particularly useful for clinical studies, including non-invasive collection, temporal stability, and lower complexity relative to other niches, such as the gut. Despite recent discoveries made in this area, it is unknown how the oral microbiome responds to short-term hospitalization. Previous studies have demonstrated that the gut microbiome is extremely sensitive to short-term hospitalization and that these changes are associated with significant morbidity and mortality. Here, we present a comprehensive pipeline for reliable bedside collection, sequencing, and analysis of the human salivary microbiome. We also develop a novel oral-specific mock community for pipeline validation. Using our methodology, we analyzed the salivary microbiomes of patients before and during hospitalization or azithromycin treatment to profile impacts on this community. Our findings indicate that azithromycin alters the diversity and taxonomic composition of the salivary microbiome; however, we also found that short-term hospitalization does not impact the richness or structure of this community, suggesting that the oral cavity may be less susceptible to dysbiosis during short-term hospitalization.
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Registered trials
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