ArticleScientific reports2017
Metabolomics differences between silkworms (Bombyx mori) reared on fresh mulberry (Morus) leaves or artificial diets.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
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- Study on the Structure and Properties of Silk Fibers Obtained from Factory All-Age Artificial Diets.International journal of molecular sciences · 2024Article
- Silkworm Hemolymph and Cocoon Metabolomics Reveals Valine Improves Feed Efficiency of Silkworm Artificial Diet.Insects · 2024Article
- Life-history stage determines the diet of ectoparasitic mites on their honey bee hosts.Nature communications · 2024Article
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- Sericin from Fibroin-Deficient Silkworms Served as a Promising Resource for Biomedicine.Polymers · 2023Review
- Metabolomics analysis of dietary restriction results in a longer lifespan due to alters of amino acid levels in larval hemolymph of Bombyx mori.Scientific reports · 2023Article
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- Nutritional Value of Silkworm Pupae (Insects · 2023Review
- Sericultural By-Products: The Potential for Alternative Therapy in Cancer Drug Design.Molecules (Basel, Switzerland) · 2023Review
- Comparative Transcriptome Analysis Identifies Key Defense Genes and Mechanisms in Mulberry (International journal of molecular sciences · 2022Article
- Metabolic characterization of hemolymph in Bombyx mori varieties after Bombyx mori nucleopolyhedrovirus infection by GC-MS-based metabolite profiling.Archives of virology · 2022Article
- Multi-tissue metabolomic profiling reveals potential mechanisms of cocoon yield in silkworms (Frontiers in molecular biosciences · 2022Article
- The differences in cocoon and silk qualities among sex-related mulberry and silkworm feeding groups.PloS one · 2022Article
- Preservative potential of biosynthesized silver nanoparticles: prevention of xylem occlusion and microbial proliferation at postharvest stage of preservation.Environmental science and pollution research international · 2021Article
- Mechanical Processing ofAnimals : an open access journal from MDPI · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silkworms (Bombyx mori) reared on artificial diets have great potential applications in sericulture. However, the mechanisms underlying the enhancement of metabolic utilization by altering silkworm nutrition are unclear. The aim of this study was to investigate the mechanisms responsible for the poor development and low silk protein synthesis efficiency of silkworms fed artificial diets. After multi-generational selection of the ingestive behavior of silkworms to artificial diets, we obtained two strains, one of which developed well and another in which almost all its larvae starved to death on the artificial diets. Subsequently, we analyzed the metabolomics of larval hemolymph by gas chromatography/liquid chromatography-mass spectrometry, and the results showed that vitamins were in critically short supply, whereas the nitrogen metabolic end product of urea and uric acid were enriched substantially, in the hemolymph of the silkworms reared on the artificial diets. Meanwhile, amino acid metabolic disorders, as well as downregulation of carbohydrate metabolism, energy metabolism, and lipid metabolism, co-occurred. Furthermore, 10 male-dominant metabolites and 27 diet-related metabolites that differed between male and female silkworms were identified. These findings provide important insights into the regulation of silkworm metabolism and silk protein synthesis when silkworms adapt to an artificial diet.
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