ArticleScientific reports2017
Neurogenetic plasticity and sex influence the link between corticolimbic structural connectivity and trait anxiety.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Intrinsic functional connectivity of motor and heteromodal association cortex predicts individual differences in regulatory focus.PNAS nexus · 2024Article
- Sex-Specific Distributed White Matter Microarchitectural Alterations in Preadolescent Youths With Anxiety Disorders: A Mega-Analytic Study.The American journal of psychiatry · 2024Article
- Sex-related Differences in Stress Reactivity and Cingulum White Matter.Neuroscience · 2021Article
- Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood.Clinical epigenetics · 2021Article
- Amygdala activity related to perceived social support.Scientific reports · 2020Article
- Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls.The American journal of psychiatry · 2019Article
- Mechanisms supporting potential use of bone marrow-derived mesenchymal stem cells in psychocardiology.American journal of translational research · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Corticolimbic pathways connecting the amygdala and ventral prefrontal cortex (vPFC) are linked with trait anxiety, but it remains unclear what potential genetic moderators contribute to this association. We sought to address this by examining the inter-individual variability in neuroplasticity as modeled by a functional polymorphism (rs6265) in the human gene for brain derived neurotrophic factor (BDNF). Amygdala-vPFC pathway fractional anisotropy (FA) from 669 diffusion magnetic resonance images was used to examine associations with trait anxiety as a function of rs6265 genotype. We first replicated the inverse correlation between trait anxiety and amygdala-vPFC pathway FA in women. Furthermore, we found a moderating influence of rs6265 genotype such that the association between trait anxiety and right amygdala-vPFC pathway FA was strongest in women carrying the Met allele, which is linked with decreased activity-dependent neuroplasticity. Results indicate that the microstructural integrity of pathways supporting communication between the amygdala and vPFC help shape the expression of trait anxiety in women, and that this association is further modulated by genetically driven variability in neuroplasticity.
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Registered trials
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