ArticleScientific reports2017
Monitoring storage induced changes in the platelet proteome employing label free quantitative mass spectrometry.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Relieving platelet inhibition using a novel bispecific antibody: a novel approach for circumventing the platelet storage lesion.Journal of thrombosis and haemostasis : JTH · 2026Article
- Platelet Storage-Problems, Improvements, and New Perspectives.International journal of molecular sciences · 2024Review
- Noninvasive Biomarkers for Alcohol-Related Liver Disease-A Proteomic Related Preliminary Report.Indian journal of clinical biochemistry : IJCB · 2024Article
- The Perspectives of Platelet Proteomics in Health and Disease.Biomedicines · 2024Review
- Structural analysis of platelet fragments and extracellular vesicles produced by apheresis platelets during storage.Blood advances · 2024Article
- The platelet storage lesion, what are we working for?Journal of clinical laboratory analysis · 2024Review
- Review
- Molecular Proteomics and Signalling of Human Platelets in Health and Disease.International journal of molecular sciences · 2021Review
- Quantitative 3D microscopy highlights altered von Willebrand factor α-granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms.Research and practice in thrombosis and haemostasis · 2021Article
- Proteomics: A Tool to Study Platelet Function.International journal of molecular sciences · 2021Review
- Current Understanding of the Relationship between Blood Donor Variability and Blood Component Quality.International journal of molecular sciences · 2021Review
- The Provocative Roles of Platelets in Liver Disease and Cancer.Frontiers in oncology · 2021Review
- Comparison of the central human and mouse platelet signaling cascade by systems biological analysis.BMC genomics · 2020Article
- Extracellular Matrix-Specific Platelet Activation Leads to a Differential Translational Response and Protein De Novo Synthesis in Human Platelets.International journal of molecular sciences · 2020Article
- The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine.Blood transfusion = Trasfusione del sangue · 2019Review
- Emerging Concepts in Immune Thrombocytopenia.Frontiers in immunology · 2018Review
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Authors and funding
9 authors.
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Abstract
Shelf life of platelet concentrates is limited to 5-7 days due to loss of platelet function during storage, commonly referred to as the platelet storage lesion (PSL). To get more insight into the development of the PSL, we used label free quantitative mass spectrometry to identify changes in the platelet proteome during storage. In total 2501 proteins were accurately quantified in 3 biological replicates on at least 1 of the 7 different time-points analyzed. Significant changes in levels of 21 proteins were observed over time. Gene ontology enrichment analysis of these proteins revealed that the majority of this set was involved in platelet degranulation, secretion and regulated exocytosis. Twelve of these proteins have been shown to reside in α-granules. Upon prolonged storage (13-16 days) elevated levels of α-2-macroglobulin, glycogenin and Ig μ chain C region were identified. Taken together this study identifies novel markers for monitoring of the PSL that may potentially also be used for the detection of "young" and "old" platelets in the circulation.
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