Evidence map›Paper›PMID 28887507›Full record

ArticleScientific reports2017

Carnosic acid prevents dextran sulfate sodium-induced acute colitis associated with the regulation of the Keap1/Nrf2 pathway.

Neng Yang, Zongling Xia, Naiyuan Shao, Bowen Li, Lian Xue, Ya Peng, Feng Zhi, Yilin Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 73 citations in OpenAlex.

  1. Biological functions and applications of rosemary extracts in animal production.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Review
  2. Antcin-H, a natural triterpene derived fromJournal of traditional and complementary medicine · 2025
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  8. Oligandrin fromHeliyon · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Neng YangOffice of Drug Clinical Trial Institution, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
Zongling XiaDepartment of Pharmacy, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
Naiyuan ShaoDepartment of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
Bowen LiModern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Lian XueModern Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Ya PengDepartment of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China. neuropengya@sina.com.
Feng ZhiDepartment of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China. danielzhif@suda.edu.cn.
Yilin YangDepartment of Neurosurgery, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China. yilinyang.czfph@gmail.com.
The First People's Hospital of Changzhou · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBDs) with high prevalence in humans. Carnosic acid (CA) has been reported to possess antioxidative properties; however, its role in IBDs has not been determined. In the present study, we found that CA significantly prevented the loss of body weight and shortening of colon length in acute colitis induced by dextran sodium sulfate (DSS). Pronounced infiltration of immune cells and a loss of crypt architecture and goblet cells were ameliorated by CA. CA significantly decreased the activity of MPO and infiltration of F4/80

Indexed as

AbietanesAnimalsColitisColonDextran SulfateGene Expression ProfilingHistocytochemistryImmunohistochemistryInflammasomesKelch-Like ECH-Associated Protein 1Mice, Inbred BALB CNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinAbietanesDextran SulfateInflammasomesKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousesalvin

Identifiers

PMID28887507
PMCPMC5591263
OpenAlexW2751271066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.