ArticleScientific reports2017
Evaluating strategies for reversing CRISPR-Cas9 gene drives.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages.Nature communications · 2024Article
- Manipulating the Destiny of Wild Populations Using CRISPR.Annual review of genetics · 2023Review
- Daisy-chain gene drives: The role of low cut-rate, resistance mutations, and maternal deposition.PLoS genetics · 2022Article
- Natural and Engineered Sex Ratio Distortion in Insects.Frontiers in ecology and evolution · 2022Article
- Gene drives gaining speed.Nature reviews. Genetics · 2022Review
- Genetic Approaches for Controlling CRISPR-based Autonomous Homing Gene Drives.Frontiers in bioengineering and biotechnology · 2022Review
- Demographic feedbacks can hamper the spatial spread of a gene drive.Journal of mathematical biology · 2021Article
- Gene drive strategies of pest control in agricultural systems: Challenges and opportunities.Evolutionary applications · 2021Article
- A common gene drive language eases regulatory process and eco-evolutionary extensions.BMC ecology and evolution · 2021Article
- Combating mosquito-borne diseases using genetic control technologies.Nature communications · 2021Review
- A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression.Nature communications · 2021Article
- Making gene drive biodegradable.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Evading resistance to gene drives.Genetics · 2021Article
- Designing gene drives to limit spillover to non-target populations.PLoS genetics · 2021Article
- Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive.PLoS genetics · 2021Article
- Analysis of a Cas12a-based gene-drive system in budding yeast.Access microbiology · 2021Article
- Split drive killer-rescue provides a novel threshold-dependent gene drive.Scientific reports · 2020Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
- Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex.Annual review of ecology, evolution, and systematics · 2020Article
- Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives.Molecular cell · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
A gene drive biases inheritance of a gene so that it increases in frequency within a population even when the gene confers no fitness benefit. There has been renewed interest in environmental releases of engineered gene drives due to recent proof of principle experiments with the CRISPR-Cas9 system as a drive mechanism. Release of modified organisms, however, is controversial, especially when the drive mechanism could theoretically alter all individuals of a species. Thus, it is desirable to have countermeasures to reverse a drive if a problem arises. Several genetic mechanisms for limiting or eliminating gene drives have been proposed and/or developed, including synthetic resistance, reversal drives, and immunizing reversal drives. While predictions about efficacy of these mechanisms have been optimistic, we lack detailed analyses of their expected dynamics. We develop a discrete time model for population genetics of a drive and proposed genetic countermeasures. Efficacy of drive reversal varies between countermeasures. For some parameter values, the model predicts unexpected behavior including polymorphic equilibria and oscillatory dynamics. The timing and number of released individuals containing a genetic countermeasure can substantially impact outcomes. The choice among countermeasures by researchers and regulators will depend on specific goals and population parameters of target populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.