Evidence map›Paper›PMID 28887458›Full record

ArticleScientific reports2017

Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy.

Stephanie G Dakin, Lucy Ly, Romain A Colas, Udo Oppermann, Kim Wheway, Bridget Watkins, Jesmond Dalli, Andrew J Carr

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Inflammatory mechanisms linking obesity and tendinopathy.Journal of orthopaedic translation · 2021
    Review
  5. Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  6. Molecular pathobiology of scleritis and its therapeutic implications.International journal of ophthalmology · 2020
    Review
  7. Article
  8. 15-Epi-LXAFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  9. Divergent roles of prostacyclin and PGEArthritis research & therapy · 2019
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Stephanie G DakinNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, OX3 7LD, UK. stephanie.dakin@ndorms.ox.ac.uk.
Lucy LyLipid Mediator Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Romain A ColasLipid Mediator Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Udo OppermannNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, OX3 7LD, UK.
Kim WhewayNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, OX3 7LD, UK.
Bridget WatkinsNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, OX3 7LD, UK.
Jesmond DalliLipid Mediator Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. j.dalli@qmul.ac.uk.ORCID 0000-0001-6328-3640
Andrew J CarrNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, OX3 7LD, UK.
Nuffield Orthopaedic Centre · GBQueen Mary University of London · GB

Funding

Medical Research Council MC_PC_14103Medical Research Council MC_PC_15069Versus Arthritis 20506Versus Arthritis 20522Wellcome Trust
6 · The paper itself

Abstract

The mechanisms underpinning the failure of inflammation to resolve in diseased musculoskeletal soft tissues are unknown. Herein, we studied bioactive lipid mediator (LM) profiles of tendon-derived stromal cells isolated from healthy donors and patients with chronic tendinopathy. Interleukin(IL)-1β treatment markedly induced prostaglandin biosynthesis in diseased compared to healthy tendon cells, and up regulated the formation of several pro-resolving mediators including 15-epi-LXA

Indexed as

AgedCells, CulturedChronic DiseaseDocosahexaenoic AcidsFemaleHumansHydroxyprostaglandin DehydrogenasesLipoxinsMaleMiddle AgedStromal CellsTendinopathy15-hydroxyprostaglandin dehydrogenase7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acidDocosahexaenoic AcidsHydroxyprostaglandin Dehydrogenaseslipoxin A4Lipoxins

Identifiers

PMID28887458
PMCPMC5591234
OpenAlexW2753094508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.