Evidence map›Paper›PMID 28887450›Full record

ArticleScientific reports2017

Effects of low concentrations of erythromycin, penicillin, and virginiamycin on bacterial resistance development in vitro.

Beilei Ge, Kelly J Domesle, Qianru Yang, Shenia R Young, Crystal L Rice-Trujillo, Sonya M Bodeis Jones, Stuart A Gaines, Marla W Keller, Xin Li, Silvia A Piñeiro and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Domain shuffling of endolysin LysKB317 to controlBiotechnology reports (Amsterdam, Netherlands) · 2026
    Article
  2. Multidrug resistance in group BJournal of medical microbiology · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Frontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Beilei GeU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Division of Animal and Food Microbiology, Laurel, Maryland, 20708, USA. beilei.ge@fda.hhs.gov.
Kelly J DomesleU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Division of Animal and Food Microbiology, Laurel, Maryland, 20708, USA.
Qianru YangU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Division of Animal and Food Microbiology, Laurel, Maryland, 20708, USA.
Shenia R YoungU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Division of Animal and Food Microbiology, Laurel, Maryland, 20708, USA.
Crystal L Rice-TrujilloU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Division of Animal and Food Microbiology, Laurel, Maryland, 20708, USA.
Sonya M Bodeis JonesU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Division of Animal and Food Microbiology, Laurel, Maryland, 20708, USA.
Stuart A GainesU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Division of Animal and Food Microbiology, Laurel, Maryland, 20708, USA.
Marla W KellerU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, Division of Animal Feeds, Rockville, Maryland, 20855, USA.
Xin LiU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, Division of Animal Feeds, Rockville, Maryland, 20855, USA.
Silvia A PiñeiroU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Division of Human Food Safety, Rockville, Maryland, 20855, USA.
Brooke M WhitneyU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Division of Human Food Safety, Rockville, Maryland, 20855, USA.
Heather C HarbottleU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Division of Human Food Safety, Rockville, Maryland, 20855, USA.
Jeffrey M GilbertU.S. Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Division of Human Food Safety, Rockville, Maryland, 20855, USA.
Center for Veterinary Medicine · USUnited States Food and Drug Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Distillers grains are co-products of the corn ethanol industry widely used in animal feed. We examined the effects of erythromycin, penicillin, and virginiamycin at low concentrations reflective of those detected in distillers grains on bacterial resistance selection. At 0.1 µg/ml erythromycin, macrolide-resistant mutants were induced in one Campylobacter coli and one Enterococcus faecium strain, while these strains plus three additional C. coli, one additional E. faecium, and one C. jejuni also developed resistance when exposed to 0.25 µg/ml erythromycin. At 0.5 µg/ml erythromycin, a total of eight strains (four Campylobacter and four Enterococcus) obtained macrolide-resistant mutants, including two strains from each genus that were not selected at lower erythromycin concentrations. For penicillin, three of five E. faecium strains but none of five Enterococcus faecalis strains consistently developed resistance at all three selection concentrations. Virginiamycin at two M

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsCampylobacterEnterococcusErythromycinMutation RatePenicillinsSelection, GeneticVirginiamycinAnti-Bacterial AgentsErythromycinPenicillinsVirginiamycin

Identifiers

PMID28887450
PMCPMC5591201
OpenAlexW2751745042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.