Evidence map›Paper›PMID 28887429›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease.

Lori Blanchfield, Joseph J Sabatino, Laurel Lawrence, Brian D Evavold

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Relationship of 2D Affinity to T Cell Functional Outcomes.International journal of molecular sciences · 2020
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lori BlanchfieldDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322.ORCID 0000-0001-9895-3421
Joseph J SabatinoDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158; and.ORCID 0000-0002-6804-7441
Laurel LawrenceDepartment of Microbiology and Immunology, Emory University, Atlanta, GA 30322.
Brian D EvavoldDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112 brian.evavold@path.utah.edu.
Emory University · USUniversity of California, San Francisco · USUniversity of Utah · US

Funding

NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)R25NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPHSON, SCOTT ANDREW · 2010 to 2023
$6.8M
CD4+ T cell affinity for self and foreign antigens in the CNSR01NS071518 · NINDS · UNIVERSITY OF UTAH · PI EVAVOLD, BRIAN D · 2010 to 2021
$3.3M
2D affinity and frequency of antigen specific TregsR01AI110113 · NIAID · UNIVERSITY OF UTAH · PI EVAVOLD, BRIAN D · 2015 to 2019
$1.9M
NIAID NIH HHS R01 AI110113NINDS NIH HHS R01 NS071518NINDS NIH HHS R25 NS070680
6 · The paper itself

Abstract

Of interest to the etiology of demyelinating autoimmune disease is the potential to aberrantly activate CD4

Indexed as

Cross ReactionsAnimalsCD4-Positive T-LymphocytesCells, CulturedEncephalomyelitis, Autoimmune, ExperimentalEpitope MappingFemaleHumansMiceMice, Inbred C57BLMice, KnockoutMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsProtein BindingReceptors, Antigen, T-CellMyelin-Oligodendrocyte Glycoproteinmyelin oligodendrocyte glycoprotein (35-55)Peptide FragmentsReceptors, Antigen, T-Cell

Identifiers

PMID28887429
PMCPMC5768416
OpenAlexW2752400833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.