ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Prior Learning of Relevant Nonaversive Information Is a Boundary Condition for Avoidance Memory Reconsolidation in the Rat Hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Theta-encoded information flow from dorsal CA1 to prelimbic cortex drives memory reconsolidation.iScience · 2025Article
- PKMζ drives spatial memory reconsolidation but not maintenance.Frontiers in synaptic neuroscience · 2025Article
- Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change.Communications biology · 2023Article
- Hippocampal CaMKII inhibition induces reactivation-dependent amnesia for extinction memory and causes fear relapse.Scientific reports · 2023Article
- Avoidance memory requires CaMKII activity to persist after recall.Molecular brain · 2021Article
- Reconsolidation of a post-ingestive nutrient memory requires mTOR in the central amygdala.Molecular psychiatry · 2021Article
- Acute Nicotine Treatment Alleviates LPS-Induced Impairment of Fear Memory Reconsolidation Through AMPK Activation and CRTC1 Upregulation in Hippocampus.The international journal of neuropsychopharmacology · 2020Article
- Cross-Frequency Phase-Amplitude Coupling between Hippocampal Theta and Gamma Oscillations during Recall Destabilizes Memory and Renders It Susceptible to Reconsolidation Disruption.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Behavioral tagging underlies memory reconsolidation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Recognition memory reconsolidation requires hippocampal Zif268.Scientific reports · 2019Article
- PKMζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- On the Involvement of BDNF Signaling in Memory Reconsolidation.Frontiers in cellular neuroscience · 2019Review
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Authors and funding
7 authors.
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Abstract
Reactivated memories can be modified during reconsolidation, making this process a potential therapeutic target for posttraumatic stress disorder (PTSD), a mental illness characterized by the recurring avoidance of situations that evoke trauma-related fears. However, avoidance memory reconsolidation depends on a set of still loosely defined boundary conditions, limiting the translational value of basic research. In particular, the involvement of the hippocampus in fear-motivated avoidance memory reconsolidation remains controversial. Combining behavioral and electrophysiological analyses in male Wistar rats, we found that previous learning of relevant nonaversive information is essential to elicit the participation of the hippocampus in avoidance memory reconsolidation, which is associated with an increase in theta- and gamma-oscillation power and cross-frequency coupling in dorsal CA1 during reactivation of the avoidance response. Our results indicate that the hippocampus is involved in memory reconsolidation only when reactivation results in contradictory representations regarding the consequences of avoidance and suggest that robust nesting of hippocampal theta-gamma rhythms at the time of retrieval is a specific reconsolidation marker.
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