ArticleMolecular & cellular proteomics : MCP2017
Proteomic Signature Reveals Modulation of Human Macrophage Polarization and Functions Under Differing Environmental Oxygen Conditions.
Article in Molecular & cellular proteomics : MCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2023Article
- Macrophage Phenotyping in Atherosclerosis by Proteomics.International journal of molecular sciences · 2023Review
- Editorial: Hypoxia and inflammation: A two-way street.Frontiers in immunology · 2023Article
- SILAC-based quantitative proteomics to investigate the eicosanoid associated inflammatory response in activated macrophages.Journal of inflammation (London, England) · 2022Article
- Proteomic characterization of phagocytic primary human monocyte-derived macrophages.RSC chemical biology · 2022Article
- Hypoxia signalling in the regulation of innate immune training.Biochemical Society transactions · 2022Review
- Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer.Cancer research · 2021Article
- Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors.Cell reports · 2021Article
- CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data.Nucleic acids research · 2021Article
- Inflaming the Brain with Iron.Antioxidants (Basel, Switzerland) · 2021Review
- Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation.Frontiers in immunology · 2021Article
- Diverse Roles of TRPV4 in Macrophages: A Need for Unbiased Profiling.Frontiers in immunology · 2021Review
- M1 and M2 Macrophages Polarization via mTORC1 Influences Innate Immunity and Outcome ofJournal of cellular immunology · 2020Article
- Decoding communication patterns of the innate immune system by quantitative proteomics.Journal of leukocyte biology · 2019Review
- Metabolic programming of macrophage functions and pathogens control.Redox biology · 2019Review
- Proteomic Profiling Unravels a Key Role of Specific Macrophage Subtypes in Sporadic Inclusion Body Myositis.Frontiers in immunology · 2019Article
- Defining the proteomic landscape of cultured macrophages and their polarization continuum.Immunology and cell biologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages are innate immune cells which can react to a large number of environmental stimuli thanks to a high degree of plasticity. These cells are involved in a variety of tissue functions in homeostasis, and they play essential roles in pathological contexts. Macrophages' activation state, which determines their functional orientation, is strongly influenced by the cellular environment. A large body of macrophage literature is devoted to better defining polarizations from a molecular viewpoint. It is now accepted that a multidimensional model of polarization is needed to grasp the broad phenotype repertoire controlled by environmental signals. The study presented here aimed, among other goals, to provide a molecular signature of various polarizations in human macrophages at the protein level to better define the different macrophage activation states. To study the proteome in human monocyte-derived macrophages as a function of their polarization state, we used a label-free quantification approach on in-gel fractionated and LysC/Trypsin digested proteins. In total, 5102 proteins were identified and quantified for all polarization states. New polarization-specific markers were identified and validated. Because oxygen tension is an important environmental parameter in tissues, we explored how environmental oxygen tension, at either atmospheric composition (18.6% O
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