Evidence map›Paper›PMID 28887331›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2017

Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.

Dante A Suffredini, Yan Li, Wanying Xu, Mahtab Moayeri, Stephen Leppla, Yvonne Fitz, Xizhong Cui, Peter Q Eichacker

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. American journal of physiology. Heart and circulatory physiology · 2021
    Article
  2. American journal of physiology. Heart and circulatory physiology · 2019
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dante A SuffrediniCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland; and.
Yan LiCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland; and.
Wanying XuCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland; and.
Mahtab MoayeriNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Stephen LepplaNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Yvonne FitzCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland; and.
Xizhong CuiCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland; and.
Peter Q EichackerCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland; and peichacker@mail.cc.nih.gov.
National Institutes of Health Clinical Center · USNational Institutes of Health · US

Funding

Vaccines and Therapeutics for AnthraxZIAAI000929 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LEPPLA, STEPHEN · 2009 to 2025
$15.9M
The Effects of Anthrax Toxins in an Aortic Ring ModelZIACL090028 · CLC · CLINICAL CENTER · PI EICHACKER, PETER · 2012 to 2020
$0k
6 · The paper itself

Abstract

Although edema toxin (ETx) and lethal toxin (LTx) contribute to

Indexed as

AdenineAnimalsAntigens, BacterialAortaArterial PressureArteriesBacterial ToxinsIn Vitro TechniquesMaleMuscle ContractionMuscle, Smooth, VascularOrganophosphonatesPhenylephrineRatsRats, Sprague-DawleyReverse Transcriptase InhibitorsadefovirAdenineanthrax toxinAntigens, BacterialBacterial ToxinsOrganophosphonatesPhenylephrineReverse Transcriptase InhibitorsVasoconstrictor Agentsadefoviranthraxarterial contractionedema toxinhypotensionlethal toxin

Identifiers

PMID28887331
PMCPMC5792197
OpenAlexW2753228489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.