Evidence map›Paper›PMID 28887315›Full record

Trial reportJournal of the American Heart Association2017

Inorganic Nitrate in Angina Study: A Randomized Double-Blind Placebo-Controlled Trial.

Konstantin Schwarz, Satnam Singh, Satish K Parasuraman, Amelia Rudd, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, Melanie Madhani, John Horowitz and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02078921 (The Effects of Inorganic Nitrate on Cardiac Muscle), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02078921 phase2completednot on this map

The Effects of Inorganic Nitrate on Cardiac Muscle: Physiology, Pharmacology and Therapeutic Potential in Patients Suffering From Angina

TypeinterventionalSponsorUniversity of AberdeenRan2012 to 2014Enrolled70ConditionsChronic Stable AnginaArmsSodium Nitrate, Placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. The unspoken benefit of participation in a clinical trial.Clinical medicine (London, England) · 2021
    Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Konstantin SchwarzSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Satnam SinghSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Satish K ParasuramanSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Amelia RuddSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Lee ShepstoneNorwich Medical School, University of East Anglia, Norwich, UK.
Martin FeelischUniversity of Southampton, Southampton, UK.
Magdalena MinnionUniversity of Southampton, Southampton, UK.
Shakil AhmadAston Medical Research Institute, Aston University, Birmingham, UK.
Melanie MadhaniInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
John HorowitzBasil Hetzel Institute, University of Adelaide, Adelaide, Australia.
Dana K DawsonSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen, UK.
Michael P FrenneauxNorwich Medical School, University of East Anglia, Norwich, UK M.Frenneaux@uea.ac.uk.
University of Aberdeen · GBUniversity of East Anglia · GBUniversity of Southampton · GBAston University · GBUniversity of Adelaide · AUUniversity of Birmingham · GB

Funding

Medical Research Council G1001536
6 · The paper itself

Abstract

backgroundIn this double-blind randomized placebo-controlled crossover trial, we investigated whether oral sodium nitrate, when added to existing background medication, reduces exertional ischemia in patients with angina. METHODS AND

resultsSeventy patients with stable angina, positive electrocardiogram treadmill test, and either angiographic or functional test evidence of significant ischemic heart disease were randomized to receive oral treatment with either placebo or sodium nitrate (600 mg; 7 mmol) for 7 to 10 days, followed by a 2-week washout period before crossing over to the other treatment (n=34 placebo-nitrate, n=36 nitrate-placebo). At baseline and at the end of each treatment, patients underwent modified Bruce electrocardiogram treadmill test, modified Seattle Questionnaire, and subgroups were investigated with dobutamine stress, echocardiogram, and blood tests. The primary outcome was time to 1 mm ST depression on electrocardiogram treadmill test. Compared with placebo, inorganic nitrate treatment tended to increase the primary outcome exercise time to 1 mm ST segment depression (645.6 [603.1, 688.0] seconds versus 661.2 [6183, 704.0] seconds,

conclusionsSodium nitrate treatment may confer a modest exercise capacity benefit in patients with chronic angina who are taking other background medication. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov/. Unique identifier: NCT02078921. EudraCT number: 2012-000196-17.

Indexed as

Administration, OralAgedAngina, StableCardiovascular AgentsCross-Over StudiesDouble-Blind MethodDrug Therapy, CombinationEchocardiography, StressElectrocardiographyExercise TestExercise ToleranceFemaleHumansMaleMiddle AgedNitratesCardiovascular AgentsNitratesNitritessodium nitrateanginaexerciseinorganic nitrateischemianitriterandomized trial

Identifiers

PMID28887315
PMCPMC5634294
OpenAlexW2753416165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.