Evidence map›Paper›PMID 28887312›Full record

ArticleDiabetes2017

Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity, and Impaired β-Cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth With Impaired Glucose Tolerance.

Joon Young Kim, Alexis Nasr, Hala Tfayli, Fida Bacha, Sara F Michaliszyn, Silva Arslanian

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. The Role of Exercise in Fat Oxidation and Its Impact on Adolescent Metabolism.Advances in experimental medicine and biology · 2026
    Review
  6. Review
  7. Anti-obesity peptides from food: Production, evaluation, sources, and commercialization.Comprehensive reviews in food science and food safety · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Effect of seaweed (Food science & nutrition · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Joon Young KimCenter for Pediatric Research in Obesity and Metabolism, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA.ORCID 0000-0003-0448-1684
Alexis NasrCenter for Pediatric Research in Obesity and Metabolism, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA.
Hala TfayliDepartment of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Fida BachaChildren's Nutrition Research Center, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-9942-1889
Sara F MichaliszynHuman Performance and Exercise Science, Youngstown State University, Youngstown, OH.
Silva ArslanianCenter for Pediatric Research in Obesity and Metabolism, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA silva.arslanian@chp.edu.ORCID 0000-0002-1528-9324
Children's Hospital of Pittsburgh · USAmerican University of Beirut Medical Center · LBChildren's Nutrition Research Center at Baylor College of Medicine · USYoungstown State University · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
T32 Research Training in Diabetes and EndocrinologyT32DK007052 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT M O'DOHERTY · 1986 to 2026
$6.3M
CHILDHOOD METABOLIC MARKERS OF ADULT MORBIDITY IN BLACKSR01HD027503 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARSLANIAN, SILVA A · 1997 to 2009
$2.1M
INSULIN RESISTANCE IN CHILDHOODK24HD001357 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARSLANIAN, SILVA A · 2000 to 2011
$1.0M
NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NICHD NIH HHS K24 HD001357NICHD NIH HHS R01 HD027503NIDDK NIH HHS T32 DK007052
6 · The paper itself

Abstract

Despite evidence of insulin resistance and β-cell dysfunction in glucose metabolism in youth with prediabetes, the relationship between adipose tissue insulin sensitivity (ATIS) and β-cell function remains unknown. We investigated whole-body lipolysis, ATIS, and β-cell function relative to ATIS (adipose disposition index [DI]) in obese youth with impaired glucose tolerance (IGT) versus normal glucose tolerance (NGT). Whole-body lipolysis (glycerol appearance rate [GlyRa], [

Indexed as

Insulin ResistanceLipolysisAdipose TissueAdolescentFemaleGlucoseGlucose IntoleranceHumansInsulin-Secreting CellsMaleObesityGlucose

Identifiers

PMID28887312
PMCPMC5697947
OpenAlexW2753186986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.