Evidence map›Paper›PMID 28887305›Full record

ArticleThe Journal of biological chemistry2017

Structural analyses of the

Karthik Sathiyamoorthy, J Vijayalakshmi, Bhramara Tirupati, Lixin Fan, Mark A Saper

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. The LpoA activator is required to stimulate the peptidoglycan polymerase activity of its cognate cell wall synthase PBP1a.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Article
  5. Review
  6. Crystal structures of the amino-terminal domain of LpoA from Escherichia coli and Haemophilus influenzae.Acta crystallographica. Section F, Structural biology communications · 2019
    Article
  7. Article
  8. Conserved mechanism of cell-wall synthase regulation revealed by the identification of a new PBP activator inProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Karthik SathiyamoorthyFrom the Program in Biophysics and.ORCID 0000-0002-5736-8709
J VijayalakshmiFrom the Program in Biophysics and.
Bhramara TirupatiFrom the Program in Biophysics and.
Lixin Fanthe Small-Angle X-ray Scattering Core Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, Maryland 21702.ORCID 0000-0002-9232-9262
Mark A SaperFrom the Program in Biophysics and saper@umich.edu.ORCID 0000-0002-0685-1071
Institute of Biophysics · BGLeidos (United States) · USUniversity of Michigan · US

Funding

Protein-protein interaction essential for bacterial growth and virulenceR21AI099984 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAPER, MARK A · 2012 to 2013
$431k
NIAID NIH HHS R21 AI099984
6 · The paper itself

Abstract

In many Gram-negative bacteria, the peptidoglycan synthase PBP1A requires the outer membrane lipoprotein LpoA for constructing a functional peptidoglycan required for bacterial viability. Previously, we have shown that the C-terminal domain of

Indexed as

Penicillin-Binding ProteinsBacterial Outer Membrane ProteinsCrystallography, X-RayEnzyme ActivatorsHaemophilus influenzaeNuclear Magnetic Resonance, BiomolecularProtein DomainsBacterial Outer Membrane ProteinsEnzyme ActivatorsPenicillin-Binding Proteinsconformational flexibilitycrystal structuregram-negative bacterianormal mode analysispeptidoglycanpeptidoglycan synthase PBP1Aprotein domainsmall-angle X-ray scattering (SAXS)transpeptidase

Identifiers

PMID28887305
PMCPMC5663868
OpenAlexW2752457481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.