ArticlePhotodiagnosis and photodynamic therapy2017
Contrast enhanced ultrasound imaging can predict vascular-targeted photodynamic therapy induced tumor necrosis in small animals.
Article in Photodiagnosis and photodynamic therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Recent Advances in Photosensitizers as Multifunctional Theranostic Agents for Imaging-Guided Photodynamic Therapy of Cancer.Theranostics · 2021Review
- Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies.Molecules (Basel, Switzerland) · 2020Review
- Role of Ultrasound and Photoacoustic Imaging in Photodynamic Therapy for Cancer.Photochemistry and photobiology · 2020Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsTo evaluate the accuracy of contrast-enhanced ultrasound (CEUS) for monitoring tumor necrosis following WST-11 vascular targeted photodynamic therapy (VTP) using imaging-pathology correlation.
methodsRenal adenocarcinoma cells were injected into the hindlimb of 13 BalB/c mice resulting in tumors ranging from 9.8 to 194.3mm
resultsTumor necrosis following VTP appeared as a central region of non-enhancement on CEUS, while viable tumor appeared as patchy regions of enhancement in the tumor periphery. The region of tumor necrosis measured in mean 66% and 64.8% of total tumor area on CEUS and pathology respectively (p=0.2). The size and location of the necrosis on CEUS images and pathology samples were found correlative with no inter-observer difference (weighted kappa of 0.771 and 0.823, respectively).
conclusionCEUS allows accurate monitoring of VTP induced tumor necrosis in a small animal model.
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