Evidence map›Paper›PMID 28887183›Full record

ArticleNeuropharmacology2017

Electrical stimulation of the hippocampal fimbria facilitates neuronal nitric oxide synthase activity in the medial shell of the rat nucleus accumbens: Modulation by dopamine D1 and D2 receptor activation.

Kristina E Hoque, Shannon R Blume, Stephen Sammut, Anthony R West

Abstract read
In one paragraph

Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kristina E HoqueDepartment of Neuroscience, Rosalind Franklin University, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Shannon R BlumeDepartment of Neuroscience, Rosalind Franklin University, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Stephen SammutDepartment of Neuroscience, Rosalind Franklin University, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Anthony R WestDepartment of Neuroscience, Rosalind Franklin University, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA. Electronic address: Anthony.west@rosalindfranklin.edu.
Rosalind Franklin University of Medicine and Science · US

Funding

Characterization of Striatal Nitric Oxide SignalingR01NS047452 · NINDS · ROSALIND FRANKLIN UNIV OF MEDICINE &SCI · PI WEST, ANTHONY R · 2004 to 2009
$1.6M
NINDS NIH HHS R01 NS047452
6 · The paper itself

Abstract

The medial shell region of the nucleus accumbens (msNAc) is a key center for the regulation of goal-directed behavior and is likely to be dysfunctional in neuropsychiatric disorders such as addiction, depression and schizophrenia. Nitric oxide (NO)-producing interneurons in the msNAc are potently modulated by dopamine (DA) and may play an important role in synaptic integration in msNAc networks. In this study, neuronal NO synthase (nNOS) activity was measured in anesthetized rats using amperometric microsensors implanted into the msNAc or via histochemical techniques. In amperometric studies, NO oxidation current was recorded prior to and during electrical stimulation of the ipsilateral fimbria. Fimbria stimulation elicited a frequency and intensity-dependent increase in msNAc NO efflux which was attenuated by systemic administration of the nNOS inhibitor N

Indexed as

AnimalsDopamine D2 Receptor AntagonistsElectric StimulationFornix, BrainInterneuronsMaleNitric Oxide Synthase Type INucleus AccumbensRats, Sprague-DawleyReceptors, Dopamine D1Receptors, Dopamine D2Dopamine D2 Receptor AntagonistsNitric Oxide Synthase Type IReceptors, Dopamine D1Receptors, Dopamine D2DopamineElectrochemistryHistochemistryNitric oxideNitric oxide synthaseNucleus accumbens medial shell

Identifiers

PMID28887183
PMCPMC5634939
OpenAlexW2752944494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.