ReviewChest2018
Diaphragm Dysfunction in Critical Illness.
Review in Chest, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 96 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation Between Muscle Thickness and Inflammation With Ventilator Length of Use in Critically Ill Patients: Study on Diaphragm Thickness, Rectus Femoris and Biceps Brachii Cross-sectional Area, and C-reactive Protein Level
Predictors of Prognosis in Patients With Critical Illness.
Effects of Mechanical Ventilation on the Diaphragm in COVID-19 Intensive Care Patients. A Post-mortem Pathology Study.
The Effect of 6 ml/kg vs 10 ml/kg Tidal Volume on Diaphragm Dysfunction in Critically Mechanically Ventilated Patient: a Randomized Clinical Trial
Who cites it
96 citing papers in PubMed, 3 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Diaphragmatic pacing for spinal cord injury patients: impact on weaning rate - a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Respiratory muscle dysfunction in mechanical ventilation: a systematic review and meta-analysis of biological mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Pooled it
- Risk factors for diaphragmatic dysfunction in mechanically ventilated patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Effects of protein, muscle rehabilitation and trunk neuromuscular electrostimulation in patients with prolonged mechanical ventilation: a prospective, randomized controlled pilot study.Annals of medicine · 2026Trial
- Transcutaneous electrical diaphragmatic stimulation in mechanically ventilated patients: a randomised study.Critical care (London, England) · 2023Trial
- A randomized controlled trial to determine whether beta-hydroxy-beta-methylbutyrate and/or eicosapentaenoic acid improves diaphragm and quadriceps strength in critically Ill mechanically ventilated patients.Critical care (London, England) · 2021Trial
- Impact of Frailty and Diaphragmatic Dysfunction on Outcomes in ARDS: Focusing on Perioperative Respiratory Management.The clinical respiratory journal · 2026Article
- Functional Assessment of the Neonatal Diaphragm Using Point-of-Care Ultrasound: A Review of Techniques, Clinical Applications, and Challenges.CHEST pulmonary · 2026Article
- Sepsis Dysregulates Mitochondrial microRNA and Biogenesis in the Diaphragm but Not Limb Muscle.International journal of molecular sciences · 2026Article
- ICU-Acquired Weakness: An Unsolved Clinical Problem: A Narrative Review.Journal of clinical medicine · 2026Review
- Correlation between swallowing and diaphragmatic functions in stroke patients with hemiplegia: a cross-sectional observational study.Scientific reports · 2026Observational
- Rehabilitating the diaphragm: an integrated approach to intensive care unit-acquired dysfunction in critical illness-a narrative review.Acute and critical care · 2026Article
- The Impact of Coronary Artery Bypass Grafting on Respiratory Function: A Systematic Review.Journal of clinical medicine · 2026Review
- Forgotten muscle: diaphragm and sudden infant death syndrome.World journal of pediatrics : WJP · 2026Article
- Application of bedside ultrasound assessment of diaphragmatic function in preparing tracheostomised patients for ventilator liberation and decannulation: a narrative review.Journal of thoracic disease · 2026Review
- Extubation Decision Support in Critical Care: A Multimodal Machine Learning Framework Integrating Segmented Radiographs and Routine Clinical Data.Journal of imaging informatics in medicine · 2026Article
- Intercostal thickening fraction adds no value to diaphragm thickening fraction in healthy subjects undergoing noninvasive ventilation.Scientific reports · 2026Article
- Prognostic Analysis of ICU Patients with Chronic Obstructive Pulmonary Disease Based on Blood Phosphate Dynamics: A Retrospective Cohort Study from the MIMIC-IV Database.International journal of chronic obstructive pulmonary disease · 2026Article
- Construction and validation of a risk prediction model for early ventilator-induced diaphragm dysfunction in mechanically ventilated patients.Frontiers in medicine · 2026Article
- Early mobilization in neurocritical care as a threshold-regulated intervention: a narrative review of mechanistic integration and implications for neurological recovery and physiological stability.Frontiers in neurology · 2026Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The diaphragm is the major muscle of inspiration, and its function is critical for optimal respiration. Diaphragmatic failure has long been recognized as a major contributor to death in a variety of systemic neuromuscular disorders. More recently, it is increasingly apparent that diaphragm dysfunction is present in a high percentage of critically ill patients and is associated with increased morbidity and mortality. In these patients, diaphragm weakness is thought to develop from disuse secondary to ventilator-induced diaphragm inactivity and as a consequence of the effects of systemic inflammation, including sepsis. This form of critical illness-acquired diaphragm dysfunction impairs the ability of the respiratory pump to compensate for an increased respiratory workload due to lung injury and fluid overload, leading to sustained respiratory failure and death. This review examines the presentation, causes, consequences, diagnosis, and treatment of disorders that result in acquired diaphragm dysfunction during critical illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.