Evidence map›Paper›PMID 28887016›Full record

ArticleDevelopmental biology2017

Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration.

Shukolpa D Roy, Victoria C Williams, Tapan G Pipalia, Kuoyu Li, Christina L Hammond, Stefanie Knappe, Robert D Knight, Simon M Hughes

Open access · hybridAbstract read
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  8. Cells · 2021
    Article
  9. Article
  10. Circadian regulation of muscle growth independent of locomotor activity.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shukolpa D RoyRandall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Victoria C WilliamsRandall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Tapan G PipaliaRandall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Kuoyu LiRandall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Christina L HammondRandall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Stefanie KnappeDivision of Craniofacial Development and Stem Cell Biology, Guy's Hospital, King's College London, UK.
Robert D KnightDivision of Craniofacial Development and Stem Cell Biology, Guy's Hospital, King's College London, UK.
Simon M HughesRandall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK. Electronic address: simon.hughes@kcl.ac.uk.
King's College London · GBGuy's Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council BB/I025883/1Biotechnology and Biological Sciences Research Council BB/K010115/1Medical Research Council G1001029Medical Research Council MR/N021231/1Wellcome Trust 101529/Z/13/Z
6 · The paper itself

Abstract

Balancing the number of stem cells and their progeny is crucial for tissue development and repair. Here we examine how cell numbers and overall muscle size are tightly regulated during zebrafish somitic muscle development. Muscle stem/precursor cell (MPCs) expressing Pax7 are initially located in the dermomyotome (DM) external cell layer, adopt a highly stereotypical distribution and thereafter a proportion of MPCs migrate into the myotome. Regional variations in the proliferation and terminal differentiation of MPCs contribute to growth of the myotome. To probe the robustness of muscle size control and spatiotemporal regulation of MPCs, we compared the behaviour of wild type (wt) MPCs with those in mutant zebrafish that lack the muscle regulatory factor Myod. Myod

Indexed as

Muscle DevelopmentAnimalsCell DifferentiationCell MovementCell NucleusCell ProliferationGlycogen Synthase Kinase 3Green Fluorescent ProteinsLarvaMuscle Fibers, SkeletalMutationPAX7 Transcription FactorSomitesZebrafishZebrafish ProteinsGlycogen Synthase Kinase 3Green Fluorescent ProteinsPAX7 Transcription FactorZebrafish ProteinsMuscleMyodMyogeninMyosinPax7Zebrafish

Identifiers

PMID28887016
PMCPMC5667637
OpenAlexW2949197523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.