Evidence map›Paper›PMID 28886763›Full record

ReviewDental clinics of North America2017

Bioactive Dental Composites and Bonding Agents Having Remineralizing and Antibacterial Characteristics.

Ke Zhang, Ning Zhang, Michael D Weir, Mark A Reynolds, Yuxing Bai, Hockin H K Xu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dental clinics of North America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Functional Adhesives for a Restorative Future.Journal of functional biomaterials · 2026
    Review
  6. Review
  7. Review
  8. Fluoride release and recharge from bioactive resinsJournal of clinical and experimental dentistry · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ke ZhangDepartment of Orthodontics, School of Stomatology, Capital Medical University, 4 Tiantanxili Street, Beijing 100050, China; Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Ning ZhangDepartment of Orthodontics, School of Stomatology, Capital Medical University, 4 Tiantanxili Street, Beijing 100050, China; Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Michael D WeirDepartment of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Mark A ReynoldsDepartment of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Yuxing BaiDepartment of Orthodontics, School of Stomatology, Capital Medical University, 4 Tiantanxili Street, Beijing 100050, China. Electronic address: byuxing@263.net.
Hockin H K XuDepartment of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA; Department of Mechanical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Cir, Baltimore County, MD 21250, USA. Electronic address: hxu@umaryland.edu.
Capital Medical University · CNUniversity of Maryland, Baltimore · US

Funding

Development of high performance, caries-inhibiting dental nano-materialsR01DE017974 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI XU, HUAKUN · 2008 to 2011
$1.0M
NIDCR NIH HHS R01 DE017974
6 · The paper itself

Abstract

Current dental restorative materials are typically inert and replace missing tooth structures. This article reviews efforts in the development of a new generation of bioactive materials designed to not only replace the missing tooth volume but also possess therapeutic functions. Composites and bonding agents with remineralizing and antibacterial characteristics have shown promise in replacing lost minerals, inhibiting recurrent caries, neutralizing acids, repelling proteins, and suppressing biofilms and acid production. Furthermore, they have demonstrated a low cytotoxicity similar to current resins, with additional benefits to protect the dental pulp and promote tertiary dentin formation. This new class of bioactive materials shows promise in reversing lesions and inhibiting caries.

Indexed as

Tooth RemineralizationAnti-Bacterial AgentsComposite ResinsDental MaterialsDentin-Bonding AgentsHumansAnti-Bacterial AgentsComposite ResinsDental MaterialsDentin-Bonding AgentsAntibacterial monomersBioactive compositesBonding agentsCalcium phosphate nanoparticlesCaries inhibitionOral biofilmsRemineralizationSilver nanoparticles

Identifiers

PMID28886763
PMCPMC5803788
OpenAlexW2752694860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.