ArticleBMC research notes2017
Correlation of cord blood telomere length with birth weight.
Article in BMC research notes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Association of depressive and/or pregnancy-related anxiety symptoms in pregnancy with maternal and neonatal biologic aging.BMC pregnancy and childbirth · 2026Article
- Parental Genetics Communicate with Intrauterine Environment to Reprogram Newborn Telomeres and Immunity.Cells · 2022Article
- Interrelationships and determinants of aging biomarkers in cord blood.Journal of translational medicine · 2022Article
- The Relationship between Telomere Length and Gestational Weight Gain: Findings from the Mamma & Bambino Cohort.Biomedicines · 2021Article
- Influence of Maternal Infection and Pregnancy Complications on Cord Blood Telomere Length.Oxidative medicine and cellular longevity · 2021Article
- Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life.PloS one · 2021Article
- Article
- Association between prenatal immune phenotyping and cord blood leukocyte telomere length in the PRISM pregnancy cohort.Environmental research · 2020Article
- Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status.The Journal of nutrition · 2020Article
- The metabolic syndrome in pregnancy and its association with child telomere length.Diabetologia · 2020Article
- In utero exposure to endocrine-disrupting chemicals and telomere length at birth.Environmental research · 2020Article
- Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation.Brain, behavior, and immunity · 2019Article
- Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight.Scientific reports · 2019Article
- Exploring telomere length in mother-newborn pairs in relation to exposure to multiple toxic metals and potential modifying effects by nutritional factors.BMC medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntrauterine growth restriction affects 3% of newborns; and the lightest 10% of whom are classified as small for gestational age (SGA). These low-birth weight newborns are at increased risk of neonatal morbidity such as hypoxia and hypoglycaemia. In later life, they are at higher risk of several age-related diseases such as cardiovascular and metabolic disorders and dementia. As having short telomeres is also associated with these diseases, we tested if these newborns might already start with shorter telomeres at birth.
findingsRelative telomere lengths were determined using quantitative real-time PCR in cord blood samples from 195 newborns of Chinese ancestry. Based on the telomere length normalised to a single copy gene and a reference DNA sample as internal control, we found statistically significant correlations between relative telomere length and both unadjusted and gestational age-adjusted birth weight, with the lighter newborns having shorter telomeres. The SGA birth weight group comprising the bottom 10% of the samples also had the shortest telomeres compared to the medium and heaviest birth weight groups.
conclusionsOur results indicate that there is reduction of cord blood telomere length for newborns with lower birth weight.
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