ArticleCell2017
Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.
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Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 239 papers.
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239citing papers in PubMed
30.9field-weighted citation impact, top 1% of its field
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Who cites it
239 citing papers in PubMed, 372 citations in OpenAlex.
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- An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid.bioRxiv : the preprint server for biology · 2026Article
- Lgr6Genes & diseases · 2026Review
- Type I interferon primes the alveolar epithelium to receive reparative signals from tissue-resident macrophages.bioRxiv : the preprint server for biology · 2026Article
- Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF).bioRxiv : the preprint server for biology · 2026Article
- Unlocking Alveolar Regeneration: AT2 Stem Cells, Signaling Networks, and Therapeutic Frontiers.Stem cell reviews and reports · 2026Review
- Identification of stem cell marker-positive subpopulations in the vocal fold of the larynx through transcriptomic analyses.Nature communications · 2026Article
- Targeting EIF5A suppresses liver fibrosis through impairment of mitochondrial function in hepatic stellate cells.Molecular and cellular biochemistry · 2026Article
- Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung.Cell reports · 2026Article
- Developmental dynamics of bronchioalveolar stem cells revealed by dual-reporter lineage tracing.Respiratory research · 2026Article
- Wnt signaling pathway in lung aging and aging-related chronic lung diseases.Biogerontology · 2025Review
- Epithelial-mesenchymal cell competition coordinates fate transitions across tissue compartments during lung development and fibrosis.Nature communications · 2025Article
- Distal lung organoids derived from adult stem cells as novel tools in deciphering mechanisms of lung regeneration, infection, and cancer.Stem cells translational medicine · 2025Review
- Post-COPD: Can Emphysema Be Repaired?American journal of respiratory and critical care medicine · 2025Article
- Loss ofAmerican journal of respiratory cell and molecular biology · 2025Article
- Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage.Science (New York, N.Y.) · 2025Article
- Mechanisms and markers of lung ageing in health and disease.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Mechanisms on How Matricellular Microenvironments Sustain Idiopathic Pulmonary Fibrosis.International journal of molecular sciences · 2025Review
179 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 8 institutions in 2 countries.
Joo-Hyeon LeeStem Cell Program and Divisions of Hematology/Oncology and Pulmonary & Respiratory Diseases, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK. Electronic address: jhl62@cam.ac.uk.
Tuomas TammelaDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Matan HofreeBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jinwook ChoiWellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Nemanja Despot MarjanovicDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Seungmin HanWellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
David CannerDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Katherine WuDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Margherita PaschiniStem Cell Program and Divisions of Hematology/Oncology and Pulmonary & Respiratory Diseases, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Dong Ha BhangDepartment of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Tyler JacksDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Aviv RegevDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Carla F KimStem Cell Program and Divisions of Hematology/Oncology and Pulmonary & Respiratory Diseases, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: carla.kim@childrens.harvard.edu.
Massachusetts Institute of Technology · USBoston Children's Hospital · USBroad Institute · USHarvard University · USHoward Hughes Medical Institute · USMedical Research Council · GBUniversity of Cambridge · GBUniversity of Pennsylvania · US
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9MMicroenvironmental control of progenitors in organ dysfunction and repairU01HL100402 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KIM, CARLA F., SCADDEN, DAVID T · 2009 to 2015
$8.5MTrinity: Transcriptome assembly for genetic and functional analysis of cancerU24CA180922 · NCI · BROAD INSTITUTE, INC. · PI HAAS, BRIAN · 2013 to 2022
$7.5MIn Vivo and In Vitro Characterization of Bronchio-Alveolar Stem CellsR01HL090136 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2007 to 2010
$1.9MSignaling pathways in lung stem cell differentiationR01HL125821 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2015 to 2018
$1.8MMechanisms of Thrombospondin-1 as a pulmonary vascular mediatorR01HL132266 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI KIM, CARLA F. · 2017 to 2020
$1.6MInvestigating Wnt and Lgr5 signaling as regulators of lung cancer heterogeneityK99CA187317 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TAMMELA, TUOMAS · 2014 to 2015
$246kEuropean Research Council 679411Medical Research Council MC_PC_12009NCI NIH HHS K99 CA187317NCI NIH HHS P30 CA014051NCI NIH HHS U24 CA180922NHLBI NIH HHS R01 HL090136NHLBI NIH HHS R01 HL125821NHLBI NIH HHS R01 HL132266NHLBI NIH HHS U01 HL100402Wellcome Trust
Abstract
The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA sequencing, and organoid culture approaches to show that Lgr5 and Lgr6, well-known markers of stem cells in epithelial tissues, are markers of mesenchymal cells in the adult lung. Lgr6
Indexed as
AnimalsHomeostasisLungMesodermMiceOrganoidsPulmonary AlveoliReceptors, G-Protein-CoupledSequence Analysis, RNASingle-Cell AnalysisTranscription, GeneticLgr5 protein, mouseLgr6 protein, mouseReceptors, G-Protein-Coupledalveolar epitheliumbronchiolar epitheliumdifferentiationlunglung stem cellsmesenchymal cellsnicheWnt signaling
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