ArticleCell stem cell2017
MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts.
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Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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100citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
100 citing papers in PubMed.
- Identification of Age-Associated Upstream Regulators to Promote Neuronal Resilience in HD Patient-Derived Neurons.Neuroscience bulletin · 2026Article
- Revisiting Pluripotency Acquisition: A Unified Framework for Reprogramming Strategies.Development, growth & differentiation · 2026Review
- MicroRNA and Alzheimer's disease: Diagnostic biomarkers and potential therapeutic targets.Neural regeneration research · 2026Article
- Three-dimensional direct neuronal reprogramming for modeling Alzheimer's disease neuropathology.Nature protocols · 2026Review
- Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The DNA Demethylase TET1 is a Pivotal Regulator of the miR-124/ISX9-Instructed Conversion of Astrocytes to Induced Neurons.Molecular neurobiology · 2026Article
- Early Reprogramming Intermediates Enable Direct Neuronal Conversion Via NGN2.Journal of molecular neuroscience : MN · 2026Article
- Direct neuronal reprogramming for neurological diseases: applications, translational Challenges, and future directions.Frontiers in neuroscience · 2026Review
- Investigation of mitochondrial phenotypes in motor neurons derived by direct conversion of fibroblasts from familial ALS subjects.Cell death & disease · 2025Article
- Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons.bioRxiv : the preprint server for biology · 2025Article
- Cell and tissue reprogramming: Unlocking a new era in medical drug discovery.Pharmacological reviews · 2025Review
- Intracellular and Extracellular Vesicle miRNA Signatures in Human iPSC-Derived Neural Stem Cells and Floor Plate Progenitors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Three-dimensional cell-cell interactions promote direct reprogramming of patient fibroblasts into functional and transplantable neurons.Science advances · 2025Article
- A drug that induces the microRNA miR-124 enables differentiation of retinoic acid-resistant neuroblastoma cells.Science signaling · 2025Article
- Lysosome repair fails in ageing and Alzheimer's disease.Nature cell biology · 2025Article
- Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs.Cell reports · 2025Article
- In Vitro and In Vivo Direct Reprogramming of Astrocytes to Induced-Neurons.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Sensory-Motor Neuropathy in Mfn2 T105M Knock-in Mice and Its Reversal by a Novel Piperine-Derived Mitofusin Activator.The Journal of pharmacology and experimental therapeutics · 2024Article
- Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming.Science (New York, N.Y.) · 2024Article
- Review
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Daniel G AbernathyDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Developmental, Regenerative, and Stem Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Woo Kyung KimDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Matthew J McCoyDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Program in Molecular Genetics & Genomics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Allison M LakeDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rebecca OuwengaDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Seong Won LeeDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xiaoyun XingDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Daofeng LiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hyung Joo LeeProgram in Molecular Genetics & Genomics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Robert O HeuckerothDepartment of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, and The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.
Joseph D DoughertyDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ting WangDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andrew S YooDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yooa@wustl.edu.
Funding
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JONATHAN P KATZ · 1997 to 2026
$32.5MUniversity of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1MTHE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTERU24ES026699 · NIEHS · WASHINGTON UNIVERSITY · PI WANG, TING · 2016 to 2021
$5.2MRESEARCH EDUCATION PROGRAM ON COMPUTATIONAL AND STATISTICAL TOOL DEVELOPMENT FOR ADDICTION GENETICSR25DA027995 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN, RICE, JOHN P. · 2009 to 2019
$4.3MMICRORNA AND NEURAL FACTOR-MEDIATED DIRECT REPROGRAMMING OF CELL FATESDP2NS083372 · NINDS · WASHINGTON UNIVERSITY · PI YOO, ANDREW · 2012 to 2017
$2.7MDECODING THE IMPACT OF TRANSPOSABLE ELEMENTS ON GENE REGULATIONR01HG007175 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2014 to 2021
$2.7MConnecting transposable elements and regulatory innovation using ENCODE dataU01HG009391 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A, FESCHOTTE, CEDRIC · 2017 to 2021
$2.4MTraining At The Interface of Psychology, Neuroscience, and GeneticsT32GM081739 · NIGMS · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2007 to 2016
$2.1MThe WashU 4DN Network Data Coordination and Integration CenterU01CA200060 · NCI · WASHINGTON UNIVERSITY · PI WANG, TING · 2015 to 2019
$1.9MADVANCED EPI/GENOME BROWSER WITH ENHANCED VISUALIZATION AND ANALYSIS TOOLSR01HG007354 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2013 to 2016
$1.5MCHARTING THE EPIGENOMIC LANDSCAPE OF HUMAN TRANSPOSABLE ELEMENTSR01ES024992 · NIEHS · WASHINGTON UNIVERSITY · PI WANG, TING · 2014 to 2015
$342kNCI NIH HHS U01 CA200060NHGRI NIH HHS R01 HG007175NHGRI NIH HHS R01 HG007354NHGRI NIH HHS U01 HG009391NIDA NIH HHS R25 DA027995NIDDK NIH HHS P30 DK050306NIEHS NIH HHS R01 ES024992NIEHS NIH HHS U24 ES026699NIGMS NIH HHS R25 GM086262NIGMS NIH HHS T32 GM081739NINDS NIH HHS DP2 NS083372
Abstract
Directed reprogramming of human fibroblasts into fully differentiated neurons requires massive changes in epigenetic and transcriptional states. Induction of a chromatin environment permissive for acquiring neuronal subtype identity is therefore a major barrier to fate conversion. Here we show that the brain-enriched miRNAs miR-9/9
Indexed as
Cellular ReprogrammingAdultCell LineageCells, CulturedChromatinChromatin Assembly and DisassemblyDNA MethylationElectrophysiological PhenomenaEpigenesis, GeneticFibroblastsGene Expression ProfilingHeterochromatinHumansMicroRNAsMotor NeuronsNeurogenesisChromatinHeterochromatinMicroRNAscell fatechromatin accessibilitychromatin remodelingdirect reprogrammingDNA methylationepigeneticshuman neuronsmicroRNAmotor neuronsneurogenesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.