Evidence map›Paper›PMID 28886363›Full record

ArticleCell stem cell2017

CRISPR: Established Editor of Human Embryos?

Xiao-Jiang Li, Zhuchi Tu, Weili Yang, Shihua Li

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. [Congenital adrenal hyperplasia].Problemy endokrinologii · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Xiao-Jiang LiMinistry of Education CNS Regeneration Collaborative Joint Laboratory, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: xli2@emory.edu.
Zhuchi TuMinistry of Education CNS Regeneration Collaborative Joint Laboratory, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
Weili YangMinistry of Education CNS Regeneration Collaborative Joint Laboratory, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
Shihua LiMinistry of Education CNS Regeneration Collaborative Joint Laboratory, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: sli@emory.edu.
Emory University · USJinan University · CN

Funding

Neuronal function of huntingtin-associated proteinR01NS036232 · NINDS · EMORY UNIVERSITY · PI ESCAYG, ANDREW P · 1998 to 2021
$6.7M
N-terminal huntingtin and Huntington disease neuropathologyR01NS101701 · NINDS · EMORY UNIVERSITY · PI ESCAYG, ANDREW P · 2017 to 2021
$2.2M
Glial huntingtin and neurodegenerationR01NS095181 · NINDS · EMORY UNIVERSITY · PI WEINSHENKER, DAVID · 2015 to 2019
$1.7M
Polyglutamine Expansion Length Dependent PathologyR01NS095279 · NINDS · EMORY UNIVERSITY · PI WARREN, STEPHEN T. · 2015 to 2019
$1.7M
NINDS NIH HHS R01 NS036232NINDS NIH HHS R01 NS095181NINDS NIH HHS R01 NS095279NINDS NIH HHS R01 NS101701
6 · The paper itself

Abstract

Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsGene EditingCRISPR-Cas SystemsHumansMosaicismMutation

Identifiers

PMID28886363
PMCPMC5819596
OpenAlexW2753824118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.