Evidence map›Paper›PMID 28886230›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2018

Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery: a prospective cohort study.

M R Grace, C J Vladutiu, R C Nethery, A M Siega-Riz, T A Manuck, A H Herring, D Savitz, J T Thorp

Open access · greenAbstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. HDL Function across the Lifespan: From Childhood, to Pregnancy, to Old Age.International journal of molecular sciences · 2023
    Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

M R GraceDepartment of Obstetrics & Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
C J VladutiuDepartment of Obstetrics & Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
R C NetheryDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
A M Siega-RizDepartments of Public Health Sciences and Obstetrics & Gynecology, University of Virginia School of Medicine, Charlottesville, VA, USA.
T A ManuckDepartment of Obstetrics & Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
A H HerringDepartment of Statistical Science and Duke Global Health Institute, Duke University, Durham, NC, USA.
D SavitzDepartments of Epidemiology and Obstetrics and Gynecology, Brown University, Providence, RI, USA.
J T ThorpDepartment of Obstetrics & Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USBrown University · USStatistical and Applied Mathematical Sciences Institute · USUniversity of Virginia · US

Funding

Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Placental Vascular Compromise and Preterm DeliveryR01HD039373 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI THORP, JOHN M · 2001 to 2005
$3.5M
UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical StudiesUG1HD040560 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI John M Thorp · 2016 to 2026
$3.3M
EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERYR01HD037584 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI SAVITZ, DAVID A · 2000 to 2004
$3.1M
NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD037584NICHD NIH HHS R01 HD039373NICHD NIH HHS UG1 HD040560
6 · The paper itself

Abstract

objectiveTo estimate the association between lipoprotein particle concentrations in pregnancy and gestational age at delivery.

designProspective cohort study.

settingThe study was conducted in the USA at the University of North Carolina. POPULATION: We assessed 715 women enrolled in the Pregnancy, Infection, and Nutrition study from 2001 to 2005.

methodsFasting blood was collected at two time points (<20 and 24-29 weeks of gestation). Nuclear magnetic resonance (NMR) quantified lipoprotein particle concentrations [low-density lipoprotein (LDL), high-density lipoprotein (HDL), very-low density lipoprotein (VLDL)] and 10 subclasses of lipoproteins. Concentrations were assessed as continuous measures, with the exception of medium HDL which was classified as any or no detectable level, given its distribution. Cox proportional hazards models estimated hazard ratios (HR) for gestational age at delivery adjusting for covariates.

main outcome measuresGestational age at delivery, preterm birth (<37 weeks of gestation), and spontaneous preterm birth.

resultsAt <20 weeks of gestation, three lipoproteins were associated with later gestational ages at delivery [large LDL

conclusionIn this sample of pregnant women, particle concentrations of VLDL TWEETABLE ABSTRACT: Nuclear magnetic resonance spectroscopy may identify lipoprotein particles associated with preterm delivery.

Indexed as

AdultDelivery, ObstetricFastingFemaleGestational AgeHumansLabor, ObstetricLipoproteinsLipoproteins, HDLLipoproteins, LDLLipoproteins, VLDLMagnetic Resonance SpectroscopyMaternal Serum Screening TestsPregnancyPremature BirthProportional Hazards ModelsLipoproteinsLipoproteins, HDLLipoproteins, LDLLipoproteins, VLDLCholesteroldyslipidaemiagestational age at deliverylipoproteinsnuclear magnetic resonance spectroscopypreterm birth

Identifiers

PMID28886230
PMCPMC6582364
OpenAlexW2752551398

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.