ArticlePloS one2017
Male-specific association of the FCGR2A His167Arg polymorphism with Kawasaki disease.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Role of long non-coding RNAs and circular RNAs in kawasaki disease: a systematic review.Pediatric rheumatology online journal · 2025Pooled it
- Etiology Model of Kawasaki Disease and Multisystem Inflammatory Syndromes: Mast Cell Activation.Current issues in molecular biology · 2026Article
- Whole-Exome Sequencing for Identification of Potential Sex-Biased Variants in Kawasaki Disease Patients.Inflammation · 2023Article
- Whole-exome sequencing analysis identifies novel variants associated with Kawasaki disease susceptibility.Pediatric rheumatology online journal · 2023Article
- Kawasaki disease and the environment: an enigmatic interplay.Frontiers in immunology · 2023Review
- Article
- Kawasaki disease in Malaysia: Biochemical profile, characterization, diagnosis and treatment.Frontiers in pediatrics · 2022Article
- Spatiotemporal clusters of Kawasaki disease in South Korea from 2008 to 2017: A municipal-level ecological study.Frontiers in pediatrics · 2022Article
- Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease.European journal of human genetics : EJHG · 2021Article
- Hygiene Hypothesis as the Etiology of Kawasaki Disease: Dysregulation of Early B Cell Development.International journal of molecular sciences · 2021Review
- Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2021Article
- Epidemiology, clinical characteristics, and immediate outcome of Kawasaki disease: a population-based study from a tropical country.European journal of pediatrics · 2021Article
- Identification of increased expression of activating Fc receptors and novel findings regarding distinct IgE and IgM receptors in Kawasaki disease.Pediatric research · 2021Article
- Association Between rs12037447, rs146732504, rs151078858, rs55723436, and rs6094136 Polymorphisms and Kawasaki Disease in the Population of Polish Children.Frontiers in pediatrics · 2021Article
- Single-Nucleotide Polymorphism LncRNA AC008392.1/rs7248320 in CARD8 is Associated with Kawasaki Disease Susceptibility in the Han Chinese Population.Journal of inflammation research · 2021Article
- Immunogenetics of Kawasaki disease.Clinical reviews in allergy & immunology · 2020Review
- Adjuvant herbal therapy for targeting susceptibility genes to Kawasaki disease: An overview of epidemiology, pathogenesis, diagnosis and pharmacological treatment of Kawasaki disease.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2020Review
- Association between the miRNA-149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population.Journal of clinical laboratory analysis · 2020Article
- Interleukin-1 Beta-Mediated Sex Differences in Kawasaki Disease Vasculitis Development and Response to Treatment.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Antibodies and Immunity During Kawasaki Disease.Frontiers in cardiovascular medicine · 2020Review
Corrections and comments
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Authors and funding
22 authors at 15 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease (KD) is an acute systemic vasculitis that can potentially cause coronary artery aneurysms in some children. KD occurs approximately 1.5 times more frequently in males than in females. To identify sex-specific genetic variants that are involved in KD pathogenesis in children, we performed a sex-stratified genome-wide association study (GWAS), using the Illumina HumanOmni1-Quad BeadChip data (249 cases and 1,000 controls) and a replication study for the 34 sex-specific candidate SNPs in an independent sample set (671 cases and 3,553 controls). Male-specific associations were detected in three common variants: rs1801274 in FCGR2A [odds ratio (OR) = 1.40, P = 9.31 × 10-5], rs12516652 in SEMA6A (OR = 1.87, P = 3.12 × 10-4), and rs5771303 near IL17REL (OR = 1.57, P = 2.53 × 10-5). The male-specific association of FCGR2A, but not SEMA6A and IL17REL, was also replicated in a Japanese population (OR = 1.74, P = 1.04 × 10-4 in males vs. OR = 1.22, P = 0.191 in females). In a meta-analysis with 1,461 cases and 5,302 controls, a very strong association of KD with the nonsynonymous SNP rs1801274 (p.His167Arg, previously assigned as p.His131Arg) in FCGR2A was confirmed in males (OR = 1.48, P = 1.43 × 10-7), but not in the females (OR = 1.17, P = 0.055). The present study demonstrates that p.His167Arg, a KD-associated FCGR2A variant, acts as a susceptibility gene in males only. Overall, the gender differences associated with FCGR2A in KD provide a new insight into KD susceptibility.
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