Evidence map›Paper›PMID 28885746›Full record

ArticleNMR in biomedicine2017

Pseudo-extravasation rate constant of dynamic susceptibility contrast-MRI determined from pharmacokinetic first principles.

Xin Li, Csanad G Varallyay, Seymur Gahramanov, Rongwei Fu, William D Rooney, Edward A Neuwelt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin LiAdvanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-9283-3602
Csanad G VarallyayDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Seymur GahramanovDepartment of Neurosurgery, University of New Mexico, Albuquerque, NM, USA.
Rongwei FuSchool of Public Health, Oregon Health & Science University, Portland, OR, USA.
William D RooneyAdvanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-0617-1540
Edward A NeuweltDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.

Funding

Two Compartment Models to Improve Brain Tumor TherapyR01CA137488 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEUWELT, EDWARD A. · 2008 to 2019
$7.3M
CNS Gene Delivery and Imaging in Brain Tumor TherapyR01NS034608 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI NEUWELT, EDWARD A. · 1996 to 2007
$3.7M
7 Tesla MRI Bolus CR Studies of Human BBB PermeabilityR01NS040801 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROONEY, WILLIAM D, SPRINGER, CHARLES S. · 2001 to 2013
$3.6M
Nondiamagnetic Agents in In Vivo 23Na and 1H2O MRR01EB000422 · NIBIB · OREGON HEALTH & SCIENCE UNIVERSITY · PI SPRINGER, CHARLES S. · 2002 to 2006
$2.3M
Human Brain Vascular Phenotyping with High-Field MRI:Water Permeability MappingR01EB007258 · NIBIB · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROONEY, WILLIAM D · 2007 to 2009
$923k
NCI NIH HHS R01 CA137488NIBIB NIH HHS R01 EB000422NIBIB NIH HHS R01 EB007258NINDS NIH HHS R01 NS034608NINDS NIH HHS R01 NS040801
6 · The paper itself

Abstract

Dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) is widely used to obtain informative perfusion imaging biomarkers, such as the relative cerebral blood volume (rCBV). The related post-processing software packages for DSC-MRI are available from major MRI instrument manufacturers and third-party vendors. One unique aspect of DSC-MRI with low-molecular-weight gadolinium (Gd)-based contrast reagent (CR) is that CR molecules leak into the interstitium space and therefore confound the DSC signal detected. Several approaches to correct this leakage effect have been proposed throughout the years. Amongst the most popular is the Boxerman-Schmainda-Weisskoff (BSW) K

Indexed as

Contrast MediaExtravasation of Diagnostic and Therapeutic MaterialsBlood VolumeHumansMagnetic Resonance ImagingContrast MediaFerumoxytolgadoliniumGjedde-Patlak transformationintravascular contrast reagentleakage correctionrelative cerebral blood volume

Identifiers

PMID28885746
PMCPMC5870763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.